Ubiquitin-proteasome system in : a potential antimalarial target to overcome resistance - a systematic review.

Background: Malaria is a devasting parasitic disease that causes over half a million deaths every year. The necessity for prompt and thorough antimalarial drug discovery and development is accelerated by the rise in multidrug resistance and the lack of an effective vaccine. The spp.

Mutation in the 26S proteasome regulatory subunit gene in confers resistance to artemisinin.

Introduction: Malaria parasites increasingly develop resistance to all drugs available in the market, hampering the goal of reducing malaria burden.

Methods: Herein, we evaluated the impact of a single-nucleotide variant, E738K, present in the 26S proteasome regulatory subunit gene, identified in resistant parasites. Plasmids carrying a functional interspecies chimeric gene with 5' recombination region from and 3' from were constructed and transfected into Dd2 parasites.