Publications by authors named "Ana L V Guedes"
Background: Inflammatory bowel disease (IBD) is associated with complications, frequent hospitalizations, surgery and death. The introduction of biologic drugs into the therapeutic arsenal in the last two decades, combined with an expansion of immunosuppressant therapy, has changed IBD management and may have altered the profile of hospitalizations and in-hospital mortality (IHM) due to IBD.
Aim: To describe hospitalizations from 2008 to 2018 and to analyze IHM from 1998 to 2017 for IBD in Brazil.
Background: Copper deficiency has been linked to alterations in lipid metabolism and hepatic steatosis. Oxidative stress plays a role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). One of the enzymes that neutralize oxidative stress is Cu/Zn superoxide dismutase, which depends on the availability of adequate amounts of copper.
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- The standard treatment for certain autoimmune diseases uses corticosteroids and thiopurines, with metabolite measurement helping non-responders identify effective strategies.
- Many patients convert thiopurines into a potentially harmful metabolite (6-MMP) instead of the desired immune-suppressing one (6-thioguanine), but adding allopurinol helps shift this balance.
- A case study shows a 51-year-old woman with autoimmune hepatitis achieved histological remission after adding allopurinol to her treatment, reducing her azathioprine dosage significantly without increased health issues.