Human skin penetration and distribution of nimesulide from hydrophilic gels containing nanocarriers.

The objective of this work was to study the in vitro skin penetration of a drug model (nimesulide) from semi-solid topical formulations containing nanospheres, nanocapsules or nanoemulsion. Nanoprecipitation, interfacial deposition and spontaneous emulsification methods were used to prepare the nanostructured suspension. The hydrodynamic diameters were 252nm for the nanoemulsion, 277nm for the nanocapsules and 202nm for the nanospheres containing nimesulide.