Mannich Bases: Promising Scaffolds for the Treatment of Infectious Diseases.

Mannich bases, synthesized through the reaction of an aldehyde, a primary or secondary amine, and a compound bearing an acidic hydrogen atom, represent a versatile class of scaffolds in medicinal chemistry. This review explores their broad spectrum of biological activities, emphasizing their potential in combating infectious diseases. With demonstrated efficacy against bacteria, fungi, and parasites, Mannich bases stand out as promising candidates for the development of novel therapeutic agents.

Microbial astaxanthin-encapsulated polymeric micelles from yeast Phaffia rhodozyma for personalized bioactive colored natural rubber latex bandages.

This study explores the development of bioactive, colored natural rubber latex (NRL) bandages by incorporating astaxanthin (AXT), a carotenoid with potent antioxidant and anti-inflammatory properties. AXT is produced by the yeast Phaffia rhodozyma under various light conditions to improve AXT biosynthesis and encapsulated in polymeric micelles to enhance its solubility and stability. The encapsulated AXT is then integrated into NRL bandages, imparting a orange-red hue and potentially therapeutic benefits.

Ex Vivo Biosafety and Efficacy Assessment of Advanced Chlorin e6 Nanoemulsions as a Drug Delivery System for Photodynamic Antitumoral Application.

The photosensitizer (PS) in the Photodynamic Therapy (PDT) field represents a key factor, being directly connected to the therapeutic efficacy of the process. Chlorin e6 is a second-generation photosensitizer, approved by the FDA with the most desired clinical properties for PDT applications, presenting high reactive oxygen species (ROS) generation and proven anticancer properties. However, hydrophobicity is a major limitation, leading to poor biodistribution.

Advances in Cysteine Protease B Inhibitors for Leishmaniasis Treatment.

The expression and release of cysteine proteases by spp. and their virulence factors significantly influence the modulation of host immune responses and metabolism, rendering cysteine proteases intriguing targets for drug development. This review article explores the substantial role of cysteine protease B (CPB) in medicinal chemistry from 2001 to 2024, particularly concerning combatting parasites.

Deficiency and Insufficiency of Vitamin D in Women of Childbearing Age: A Systematic Review and Meta-analysis.

Objective:  To estimate the prevalence of inadequate vitamin D level and its associated factors for women of childbearing age in Brazil.

Methods:  A systematic review was conducted (last updated May 2020). Meta-analyses were performed using the inverse-variance for fixed models with summary proportion calculation by Freeman-Tukey double arcsine.

Deficiency of vitamins C and E in women of childbearing age in Brazil: a systematic review and meta-analysis.

Background: Despite the several options available for supplements containing vitamins C and E, evidence regarding the prevalence of deficiency or insufficiency of these vitamins is weak.

Objectives: To estimate the prevalence of deficiency or insufficiency of vitamins C and E and associated factors among women of childbearing age, in Brazil.

Design And Setting: Systematic review and meta-analysis conducted at a Brazilian public university.