Publications by authors named "Ana J Garcia-Malinis"

The care of psoriatic patients requires a multidisciplinary approach that addresses not only skin involvement but also cardiovascular risk factors. Coordination between dermatology and internal medicine departments, with a specific focus on treatment and long-term follow-up, can substantially improve the course of a disease and its associated complications. Objective: to evaluate the effects of the holistic management of patients with psoriasis by a multidisciplinary team consisting of dermatology and internal medicine specialists.

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Background: Solar ultraviolet radiation (UVR) is one of the main risk factors for non-melanoma skin cancer. In Spain, 11% of the population are outdoor workers. Farmers are among the outdoor workers with the highest levels of chronic sun exposure.

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Background: Appearance-based interventions emphasize how UV exposure contributes to the premature aging of skin.

Objectives: The current study was aimed at evaluating the impact of self-assessed skin damage based on UV imaging on the intention to modify photoprotection habits.

Materials & Methods: A prospective observational study was performed.

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Background And Objectives: The incidence of skin cancer in our society is growing at an alarming rate due to overexposure to solar UV radiation in recreational and occupational settings. The aim of this study was to evaluate sun exposure and protection attitudes, behaviors, and knowledge among mountain ultramarathon runners and to assess risk factors for sunburn in this population.

Material And Methods: Cross-sectional survey of runners who participated in the «Gran Trail Aneto-Posets» race in Aragon, Spain.

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Background: Snow reflectivity and altitude increase the exposure of ski resort workers to solar ultraviolet radiation. The aim was to assess the presence of skin cancer in ski resorts workers and compare it with other groups of outdoor workers reviewing published studies.

Methods: An observational cross-sectional prospective study was conducted in the three largest ski resorts in Spain: Baqueira Beret, Lleida; Formigal, Huesca and Sierra Nevada, Granada.

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Background: Previous studies have linked low serum vitamin D (VD) or 25-hydroxyvitamin D (25(OH)D) levels with increased severity of atopic dermatitis (AD) in children.

Objective: To investigate the association between serum VD (25(OH)D) levels and AD and AD severity, considering the influence of diet and sun exposure.

Methods: We performed a prospective cross-sectional study of healthy controls and children diagnosed with AD.

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Background/objectives: The association between atopic dermatitis, body weight and serum lipid levels is not well known, and very few studies have examined this relationship in children.

Methods: Children (n = 239) under 14 years old participated in this prospective cross-sectional study. The following variables were recorded: age, gender, weight, height, atopic dermatitis severity, serum levels of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides.

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The microorganisms that cause infections are increasing their resistance to antibiotics. In this context, alternative treatments are necessary. The antimicrobial photodynamic therapy (aPDT) is a therapeutic modality based on photosensitizing molecules that end up generating reactive oxygen species that induce the destruction of the target cells when are irradiated with light of a suitable wavelength and at a proper dose.

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Background: TRPV4 channels are calcium-permeable cation channels that are activated by several physicochemical stimuli. Accordingly, TRPV4 channels have been implicated in the regulation of osmosensing, mechanotransduction, thermosensation, and epithelial/endothelial barrier functions. Whether TRPV4 is also mechanistically implicated in melanoma cell proliferation is not clear.

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Background: Therapies used to treat chondrodermatitis nodularis helicis (CNH), such as surgical excision, pressure relief, or topical steroids report varying degrees of success.

Objective: We evaluated the response and safety of methyl aminolevulinate (MAL) photodynamic therapy (PDT) in CNH.

Methods: This retrospective, observational study performed at the University Hospital Ramon y Cajal (Madrid, Spain) and Hospital San Jorge (Huesca, Spain) included all patients diagnosed with CNH and treated with MAL-PDT from 2008 to 2015.

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The calcium/calmodulin-gated KCa3.1 channel regulates normal and abnormal mitogenesis by controlling K-efflux, cell volume, and membrane hyperpolarization-driven calcium-entry. Recent studies suggest modulation of KCa3.

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