Thrombin generation and international normalized ratio in inherited thrombophilia patients receiving thromboprophylactic therapy.

Background: Thrombin generation assay (TGA) is useful as a global functional test for assessing bleeding or thrombotic risk and its modification with therapy. We investigated TGA to assess anticoagulation status compared with the international normalized ratio (INR) system in patients with primary thrombophilia receiving and not undergoing thromboprophylaxis.

Materials And Methods: We studied 50 patients with at least one thrombotic event and a confirmed diagnosis of inherited thrombophilia.