Publications by authors named "Ana Iglesias-Alonso"
Article Synopsis
- This international guideline suggests enhancing clozapine package inserts by implementing ancestry-based dosing and titration to reduce adverse drug reactions (ADRs).
- Clozapine, a powerful medication, has a narrow therapeutic range and is highly associated with toxicity, especially in certain populations; it is especially risky due to its high rates of pneumonia-related mortality.
- The guideline outlines six personalized dosing schedules based on ancestry and metabolic activity, recommending varying daily doses of clozapine tailored to individual patient profiles to minimize the risk of ADRs.
Purpose/background: A nomogram from a British naturalistic study proposed that the clozapine dosing needed to reach a serum concentration of 350 ng/mL ranged from 265 mg/d (female nonsmokers) to 525 mg/d (male smokers). Some European reviews have used these dosing recommendations, which seem greater than what we found in an Italian White sample ranging from 245 mg/d (female nonsmokers) to 299 mg/d (male smokers). Five other published samples of European Whites were added to the Italian sample to estimate clozapine doses recommended for reaching 350 ng/mL.
View Article and Find Full Text PDFConcentrations in plasma clozapine levels in schizophrenic and schizoaffective patients.
Rev Psiquiatr Salud Ment
July 2018
Introduction: There is great variability in plasma levels of clozapine. The objective of this study is to know the characteristics of patients treated with clozapine and the relationship between them and the variability of plasma levels.
Material And Methods: Descriptive, cross-sectional study of all patients currently treated with clozapine in a Psychiatric Service with a diagnosis of schizophrenic psychosis or schizoaffective disorder.