Draft Genome Sequences of Three Salmonella enterica Serovar 4,[5],12:i:- Strains and One S. enterica Serovar Typhimurium Strain, Isolated in Brazil.

Draft genomes of three 4,[5],12:i:- (STi) strains isolated from human infections were obtained using Illumina sequencing. They were negative for the operon but positive for , and k-mer analyses revealed their identity as 4,[5],12:i:- 08-1736 and Typhimurium. A draft Typhimurium sequence is described for comparison.

Synthesis, biological evaluation, and structure-activity relationships of potent noncovalent and nonpeptidic cruzain inhibitors as anti-Trypanosoma cruzi agents.

The development of cruzain inhibitors has been driven by the urgent need to develop novel and more effective drugs for the treatment of Chagas' disease. Herein, we report the lead optimization of a class of noncovalent cruzain inhibitors, starting from an inhibitor previously cocrystallized with the enzyme (K(i) = 0.8 μM).