Family dynamics and support network of family caregivers of people with progressive cancer.

Objective: To analyze family dynamics, the support network of family caregivers of individuals with progressive cancer, and their needs for comprehensive care.

Method: Qualitative, descriptive study developed based on the Calgary Family Assessment Model framework. It was conducted from September 2022 to April 2023, through participant observation at a public health institution in São Paulo and interviews with six family caregivers.

Phone call for diabetic people: protocol for a pragmatic, type 1 effectiveness-implementation hybrid clinical trial.

Objective: To describe an implementation study protocol for an intervention based on educational guidelines focused on seven self-care behaviors, through phone calls to individuals with type 2 diabetes.

Method: We will conduct a hybrid type 1 effectiveness-implementation pragmatic randomized clinical trial, with 198 individuals with type 2 diabetes on insulin therapy, from the Glycemic Self-Monitoring Program of two Primary Health Care in the city of São Paulo and three in Campinas, located in the state of Sao Paulo. Patients will be allocated in a 1:1 ratio to either the intervention or control group.

Using spatial analysis to examine inequalities and temporal trends in food retail accessibility.

Objective: In this paper, we examined whether there are inequalities in access to food retail (by type and healthiness) across local government areas (LGA) in Greater Melbourne and by LGA grouped based on their distance from the central business district and Growth Area designation. We also examined whether these inequalities persisted over time.

Design: This is a secondary analysis of a repeated cross-sectional census of food outlets collected at four time points (2008, 2012, 2014 and 2016) across 31 LGA.

Effectiveness, durability and safety of dolutegravir and lamivudine versus bictegravir, emtricitabine and tenofovir alafenamide in a real-world cohort of HIV-infected adults.

Objective: Dolutegravir plus lamivudine (2-DR) is suggested as an initial and switch option in HIV-1 treatment. The aim of this study was to analyze the effectiveness, durability, and safety of 2-DR compared to bictegravir/emtricitabine/tenofovir alafenamide (3-DR).

Patients And Methods: This was an observational, ambispective study that included all treatment-naïve (TN) and treatment-experienced (TE) people living with HIV/AIDS (PLWH), who started 2-DR or 3-DR between 01 July 2018, and 31 January 2022.

Broad Scale Spatial Modelling of Wet Bulb Globe Temperature to Investigate Impact of Shade and Airflow on Heat Injury Risk and Labour Capacity in Warm to Hot Climates.

While shade and air flow are recognised factors that reduce outdoor heat exposure, the level of reduction in terms of labour capacity at varying air temperature and humidity levels is poorly understood. This study investigated cooling effects on the commonly used heat index, wet bulb globe temperature (WBGT), and subsequent impact on labour capacity, for a range of air flow and shade conditions in warm to hot climates. We modelled heat exposure using a physics-based method to map WBGT for a case study region which experiences a range of heat categories with varying levels of health risks for outdoor workers.

Vulnerability and quality of life of older persons in the community in different situations of family care.

Objective: to correlate socio-contextual aspects, physical vulnerability and quality of life of older persons in the community in different situations of family care.

Methods: epidemiological, a cross-sectional and analytical study, with elderly people in the community (n=769), with application of the instruments: Vulnerable Elders Survey-13 (VES-13), World Health Organization Quality of Life for Older Persons (WHOQOL-OLD) and the World Health Organization Quality of Life (WHOQOL-BREF); and socio-contextual data questionnaire.

Results: the population assessed presented an average of regular quality of life in both the WHOQOL-BREF and the WHOQOL-OLD.

Family members seeking compulsory hospitalization for drug-using members: profile, expectations and needs.

Objective: to outline the profile and understand the expectations and needs of family members who seek compulsory hospitalization for drug-using members.

Method: Mixed research; data collected involving 101 medical records and semi-structured interviews with 26 family members. SPSS software and content analysis was used.

Mindfulness-Based Versus Story Reading Intervention in Public Elementary Schools: Effects on Executive Functions and Emotional Health.

Introduction: In this study we compared the effects of a mindfulness-based intervention (MBI) with a story reading intervention (SI) on the executive functions and psychological profile of children in two different public schools in São Paulo, Brazil.

Methods: In this controlled clinical trial, 207 children aged 8 to 9 years old responded to the Five-Digit Test (FDT), stress levels, depression, anxiety, positive and negative affect, at baseline (T0) and 8 weeks later (T1). From T0 to T1, school 1 participated in MBI classes and school 2 in IS classes.

Prevalence, consequences and factors associated with drug use among individuals over 50 years of age in the family perspective.

Objectives: The aim of this study was to investigate the prevalence, consequences and factors associated with drug use among individuals over 50 years of age, from the perspective of their families, with particularly reference to cocaine use.

Methods: Cross-sectional study based on secondary data with 624 family members of substance users who sought family support in 14 units of the Program in São Paulo, Brazil.

Results: The participants were predominately men, aged 50 to 59 years (68%); cocaine users (inhaled and/ or smoked); living alone; with a low level of education and were unemployed.

Mortality events resulting from Australia's catastrophic fires threaten aquatic biota.

The consequences of the 2019-2020 bushfires in Australia were also devastating for the aquatic biota. Following abnormal rainfall events in burnt areas, widespread mortality events including fish and invertebrates were recorded in estuarine and freshwater systems. Such negative impacts on aquatic resources highlight the need to include these ecosystems in bushfire recovery plans.

The aging of families with members with intellectual disabilities.

Objective: to understand the structure and dynamics of families in the late stage of the life cycle that have a member with intellectual disability.

Method: qualitative research using the Calgary Family Assessment Model as methodological framework. The study had 38 participants, distributed into 10 families that had a member with intellectual disability and whose parents were elderly.

Definition of Immunological Nonresponse to Antiretroviral Therapy: A Systematic Review.

Background: Terms and criteria to classify people living with HIV on antiretroviral therapy who fail to achieve satisfactory CD4 T-cell counts are heterogeneous, and need revision and summarization.

Methods: We performed a systematic review of PubMed original research articles containing a set of predefined terms, published in English between January 2009 and September 2018. The search retrieved initially 1360 studies, of which 103 were eligible.

Comprehensiveness in the perspective of public health: pathways for the training of the nurse.

Objective: to present an academic practice experienced by professors in a curricular unit of the public health field entitled "Comprehensive health care", offered in the undergraduate nursing course of a public university.

Methods: experience report of dialogic activities between professors and undergraduates.

Results: it was possible to discuss nursing care from the perspective of comprehensiveness, which allowed the understanding of the need to broaden the scope regarding the practices conducted in primary care and enabled the attribution of new meanings to the actions experienced by undergraduate students in their curricular internships; thus, contributing to the training of a professional with critical and creative capacity.

Thymic Function as a Predictor of Immune Recovery in Chronically HIV-Infected Patients Initiating Antiretroviral Therapy.

Poor immunological responders (PIR) are HIV-infected patients with virologic suppression upon antiretroviral therapy (ART) but persistently low CD4 T cell counts. Early identification of PIR is important given their higher morbimortality compared to adequate immune responders (AIR). In this study, 33 patients severely lymphopenic at ART onset, were followed for at least 36 months, and classified as PIR or AIR using cluster analysis grounded on their CD4 T cell count trajectories.

Nursing and light technologies for a peace culture within the family.

Objective: To reflect on technologies for the peace culture that can be used in family nursing.

Method: Theoretical essay, based on the premises of non-violence and peace culture.

Results: Four light technologies are singled out for the peace culture within families: nonviolent communication, qualified listening, conflict mediation, and restorative circles.

Violence in health care settings: rethinking actions.

Objective: To present a reflection on the forms of violence in health care settings and on preventive actions.

Method: This is a theoretical reflection about the phenomenon of violence and its possible coping actions.

Results: Nurses and other professionals working in health care environments may experience situations of aggression and disrespect through institutional or managerial violence, horizontal violence and patient violence.

Glomerular filtration rate change during chronic hepatitis C treatment with Sofosbuvir/Ledipasvir in HCV/HIV Coinfected patients treated with Tenofovir and a boosted protease inhibitor: an observational prospective study.

Introduction: Concomitant use of ledipasvir and boosted protease inhibitors (PIs) may increase the risk of tenofovir (TDF) nephrotoxicity, since both these drugs increase TDF levels. Our aim was to evaluate glomerular filtration rate (eGFR) evolution during HCV treatment with sofosbuvir/ledipasvir (SOF/LDV) in HCV/HIV coinfected patients, according to their antiretroviral treatment (ARV).

Methods: Observational prospective study of HCV/HIV coinfected patients treated with SOF/LDV.

Family composing the soundtrack of its reintegration: a theoretical model.

Objective: to understand the meaning of the family's reintegration attributed by the family experiencing it and to construct a representative theoretical model of this experience.

Method: this is a qualitative study, conducted with four families with a total of 20 interviewees, with Symbolic Interactionism as theoretical framework, Grounded Theory as methodological, participant observation and the experience of musical making, mediating the interview as strategies of data collection.

Results: a comparative analysis of the data led to the identification of the main category and to the construction of the theoretical model TRYING TO REBUILD WHAT WAS BROKEN.

The family in face of the elderly's reality of living alone.

Objective: to understand the family dynamics in face of the reality of the elderly living alone.

Method: study of qualitative approach with theoretical reference of symbolic interactionism that involved interviews with families. Data were analyzed by thematic analysis.

Toxoplasmosis-associated IRIS involving the CNS: a case report with longitudinal analysis of T cell subsets.

Background: HIV-infected patients may present an unforeseen clinical worsening after initiating antiretroviral therapy known as immune reconstitution inflammatory syndrome (IRIS). This syndrome is characterized by a heightened inflammatory response toward infectious or non-infectious triggers, and it may affect different organs. Diagnosis of IRIS involving the central nervous system (CNS-IRIS) is challenging due to heterogeneous manifestations, absence of biomarkers to identify this condition, risk of long-term sequelae and high mortality.

Experience and coping strategies in relatives of addicts.

Objective:: to understand the experience and coping strategies in relatives of drug addicts.

Method:: a study was developed with 87 relatives of addicts, registered in two Basic Health Units. The focus group was used as the study method, and content analysis was applied.

[Family dynamics in face of Alzheimer's in one of its member].

Objective: To understand the family dynamics when there is a member in the residence with Alzheimer's disease.

Method: A study of qualitative approach, using the creative sensitive method (CSM), and with participation of two families who had a member with Alzheimer's disease at home.

Results: Three categories emerged: Effects of Alzheimer's disease and the family dynamics; Development process of Alzheimer's disease and Coping strategies in face of the disease.

Longitudinal evaluation of regulatory T-cell dynamics on HIV-infected individuals during the first 2 years of therapy.

Objectives: A sizeable percentage of individuals infected by HIV and on antiretroviral therapy (ART) fail to increase their CD4 T-cells to satisfactory levels. The percentage of regulatory T-cells (Tregs) has been suggested to contribute to this impairment. This study aimed to address this question and to expand the analysis of Tregs subpopulations during ART.