Publications by authors named "Ana Higuero"
J Mol Med (Berl)
March 2014
Article Synopsis
- Mitochondrial glutaminase (GA) is crucial for cancer cell metabolism, but the specific roles of its isozymes (KGA and GAB) in cancer are not fully understood.
- Silencing KGA in glioma cells led to reduced cell survival, increased apoptosis markers, and mitochondrial dysfunction, while GAB overexpression showed different but significant effects.
- Combining GA expression modulation with oxidizing agents like arsenic trioxide or hydrogen peroxide enhances the therapeutic effects against glioma cells, suggesting a new approach for cancer treatment.
