What is the role of circRNAs in the pathogenesis of cervical cancer? A systematic literature review.

Cervical Cancer (CC) is one of the most prevalent neoplasms among women, considered the leading cause of gynecological death worldwide, and the fourth most common type of cancer. Regional metastasis is closely related to the low effectiveness of treatment, and validating biomarkers can optimize accuracy in diagnosis and prognosis. Among the potential biomarkers associated with disease metastasis are circular RNAs (circRNAs), whose altered expression has been linked to CC progression.

Factors associated with lack of mammography: National Health Survey, 2013.

Introduction: Mammography is the main screening test for early detection of breast cancer; however, its access is not equal for all women in Brazil. The objective of this study was to analyze the factors associated with not having this examination done in a period of less than two years in Brazil and according to macro-region, considering sociodemographic characteristics, health conditions, lifestyle, and the use of health services.

Method: Cross-sectional study using data from the National Health Survey in Brazil (Pesquisa Nacional de Saúde - PNS).

Pathophysiological mapping of tumor habitats in the breast in DCE-MRI using molecular texture descriptor.

Background: We propose a computational methodology capable of detecting and analyzing breast tumor habitats in images acquired by magnetic resonance imaging with dynamic contrast enhancement (DCE-MRI), based on the pathophysiological behavior of the contrast agent (CA).

Methods: The proposed methodology comprises three steps. In summary, the first step is the acquisition of images from the Quantitative Imaging Network Breast.

TP53 mutations in primary breast carcinomas from white and African-Brazilian patients.

We have attempted to determine the incidence, nature and clinical significance of TP53 mutation in a group of white (242 cases) and African-Brazilian (52 cases) patients with breast cancer. The interethnic admixture as estimated by STR markers showed that white subjects displayed 67.9+/-0.