Preventing opioid prescription after major surgery: a scoping review of opioid-free analgesia.

Background: Excessive opioid prescribing after surgery has been recognised as a contributor to the current crisis of opioid addiction and overdose. Clinicians may potentially tackle this crisis by using opioid-free postoperative analgesia; however, the scientific literature addressing this approach is sparse and heterogeneous, thereby limiting robust conclusions. A scoping review was conducted to systematically map the extent, range, and nature of the literature addressing postoperative opioid-free analgesia.

ESR dating of Smilodon populator from Toca de Cima dos Pilão, Piauí, Brazil.

Smilodon is a genus of big cats that lived from the early to the late Pleistocene in regions extending from North to South America. The fossil records of the "saber-toothed cats" are uneven, with some taxa being quite abundant in certain regions. In Brazil, Smilodon populator is a well-known species whose remains, although scarce in comparison to other large mammals, are found all across the country.

The effect of the aqueous extract Peumus boldus on the proliferation of hepatocytes and liver function in rats submitted to expanded hepatectomy.

Purpose:: To assess the effect of aqueous extract of Peumus Boldus (AEPB) on the liver proliferative response after parcial hepatectomy of 70% (PH) in rodents.

Methods:: Twenty Wistar rats were divided in two groups: AEPB100 (whose rats received 100mg/Kg of AEPB, once a day, orally, in 4 days prior to the first surgical procedure) and Vehicle (whose rats were treated similarly with distilled water). Both groups underwent PH.