Publications by authors named "Ana G da Costa"

Background: Since the seminal publication of the TCGA consortium in 2013, the molecular classification of endometrial cancer has been widely accepted as a new and powerful tool to better understand the natural history of this malignancy. Adoption of routine molecular classification around the world has been limited. We sought to demonstrate our initial experience in incorporating the four molecular subtypes for endometrioid carcinomas.

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Article Synopsis
  • Treatment for recurrent ovarian cancer primarily relies on systemic therapy, but recent trials are exploring the potential benefits of secondary cytoreductive surgery.
  • Imaging is crucial for identifying patients with resectable disease, as various imaging techniques and staging laparoscopy have sparked significant debate in the medical community.
  • The first reported case of using 3D modeling for planning secondary cytoreductive surgery in a recurrent ovarian cancer patient demonstrated its effectiveness in assessing disease extent, leading to a successful surgery and disease-free status for the patient.
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Background: POLE mutated endometrial carcinomas may represent a subspecific type of tumors harboring a more favorable prognosis. Grade 3 (G3 or high-grade) endometrioid endometrial carcinomas remain a clinical dilemma, with some tumors behaving as the low-grade counterparts and others presenting a more aggressive behavior.

Objectives: To determine the association between POLE mutational status and the overall-survival (OS) and progression-free-survival (PFS) of patients with G3 endometrioid endometrial cancer (EC).

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Study Objective: To evaluate the outcomes of extraperitoneal para-aortic lymphadenectomy by robot-assisted laparoscopy.

Design: A retrospective study (Canadian Task Force classification III).

Setting: An academic institution.

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Aim: To compare transvaginal digital examination performed by residents and attending physicians to transabdominal suprapubic ultrasound in the evaluation of fetal head position in the second stage of labor.

Methods: A prospective study was conducted at a tertiary center and included pregnant women at term, with normal singleton cephalic presentation fetuses. All patients had ruptured membranes and were evaluated during the second stage of labor.

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