Publications by authors named "Ana Florica Chis"

Background And Aims: Gaucher disease (GD) is one of the most common lysosomal storage diseases. It is characterized by the accumulation of glucocerebroside lipids in the macrophages, with liver, spleen and bone marrow frequently affected. The affected organs can develop tumor-like lesions (Gaucheromas), which are difficult to diagnose.

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: Chronic obstructive pulmonary disease (COPD) represents a debilitating disease, with rising morbidity and mortality. Vascular endothelial growth factor (VEGF) plays a major role in angiogenesis, vascular permeability, and airway remodeling. The purpose of this study was to investigate the relationship between VEGF serum levels and VEGF +936 C/T gene polymorphism (rs3025039) with COPD, for the first time in a Romanian population.

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Background: Despite efforts at treatment, obstructive sleep apnea (OSA) remains a major health problem, especially with increasing evidence showing an association with cardiovascular morbidity and mortality. The treatment of choice for OSA patients is Continuous Positive Airway Pressure (CPAP), which has been proven in randomized controlled trials to be an effective therapy for this condition. The impact of CPAP on the cardiovascular pathology associated with OSA remains, however, unclear.

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Gaucher disease (GD) is a rare genetic disease caused by the enzymatic deficiency of beta-glucocerebrosidase. This will lead to the accumulation of sphingolipids in various organs, such as liver, spleen, bone marrow. Bone involvement is frequent in Gaucher patients, leading to bone pain, necrosis and even fractures or growth deficiency in children, with painful surgeries and progressively decreasing quality of life.

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Gaucher disease is a rare autosomal recessive disease caused by the beta-glicosidase activity deficiency, which will lead to substrate accumulation mainly in the liver, spleen or bone marrow. The main symptoms are liver and spleen enlargement, anemia and low platelet count, bone crisis and fatigue. Several treatment options are available, as enzyme replacement therapy, substrate reduction therapy, or chaperones treatment whose effect is still studied.

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Pulmonary alveolar proteinosis (PAP) is a rare lung disease characterized by an abnormal intra-alveolar accumulation of surfactant derived lipoproteinaceous compounds, leading to dyspnea and, in severe cases, to respiratory failure. The most common form of PAP is the auto-immune one. Secondary PAP has been recognized in myeloid leukemia, non-hematological neoplasms, lung infections or environmental exposure to noxious particles.

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Inflammation has an important role in the progression of various viral pneumonia, including COVID-19. Circulating biomarkers that can evaluate inflammation and immune status are potentially useful in diagnosing and prognosis of COVID-19 patients. Even more so when they are a part of the routine evaluation, chest CT could have even higher diagnostic accuracy than RT-PCT alone in a suggestive clinical context.

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Article Synopsis
  • Precision medicine in lung cancer research has led to improved patient survival and quality of life, especially through targeted therapies for non-small cell lung cancer (NSCLC) with ALK gene rearrangement.* -
  • This review highlights ALK tyrosine kinase inhibitors (TKIs), their mechanisms of action and resistance, various gene detection methods, and future research aimed at overcoming resistance.* -
  • Crizotinib was the first approved TKI and while newer drugs like alectinib and brigatinib have been developed, resistance remains a significant challenge with half of the resistance mechanisms still unidentified.*
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  • - The study examines how well pulmonologists follow the 2017 GOLD guidelines for treating chronic obstructive pulmonary disease (COPD), revealing a 79.02% adherence rate among 348 stable outpatient individuals.
  • - The most common treatments prescribed were a combination of long-acting beta agonists (LABA) and long-acting antimuscarinic agents (LAMA), but inappropriate treatment was notably high, especially in lower-risk Groups A and B.
  • - Factors influencing poor adherence include patients with cardiovascular comorbidities, who were almost twice as likely to receive inappropriate therapy, and the tendency to overprescribe inhaled corticosteroids (ICS), particularly in higher-risk patients.
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  • COVID-19 is a highly contagious disease declared a pandemic by the WHO, which put significant emotional strain on healthcare workers as they balanced their clinical responsibilities and family obligations.
  • A study assessing 115 healthcare workers from a pulmonology teaching hospital found high levels of stress and emotional distress during the first month of the outbreak, regardless of whether they worked in COVID-19 or non-COVID-19 departments.
  • Both groups exhibited similar disease perceptions and coping mechanisms, with a tendency to use strategies like planning and positive reappraisal more than the general population.
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Background And Aims: Chronic obstructive pulmonary disease (COPD) is currently the third leading cause of death worldwide, with increasing mortality and morbidity. The neutrophil to lymphocyte ratio (NLR) and blood eosinophils level (EOS) represent biomarkers of inflammation in various diseases, with current research in the field of COPD. The aim of this study was to determine correlations of NLR and EOS with certain characteristics of COPD in a group of patients without major comorbidities.

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The metabolic syndrome leads to high morbidity and mortality. Almost all pathological states are associated with oxidative stress (OS) disorders. This study evaluates the effects of Coenzyme Q10 (CoQ10) supplementation on different lifestyles, in relation to serum and tissue OS parameters.

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