Publications by authors named "Ana Flavia Marques Pereira"
Article Synopsis
- Honeybee stings can lead to various health issues, from mild local reactions to serious systemic effects, highlighting it as a public health concern.
- The review discusses the mechanisms of envenoming, different clinical presentations, and the importance of accurate diagnosis for effective treatment.
- It also evaluates new diagnostic technologies and treatment strategies to enhance patient care and outcomes for those affected by honeybee stings.*
Article Synopsis
- * Animal venoms, sourced from various species like snakes and mollusks, are being studied for their potential analgesic properties as they contain biomolecules that could help manage different types of pain.
- * The exploration of venom-derived toxins could lead to new pain treatment methods, with an emphasis on developing multimodal therapies that utilize these natural compounds to enhance pain management strategies.
Methicillin-resistant (MRSA) often cause infections with high mortality rates. Antimicrobial peptides are a source of molecules for developing antimicrobials; one such peptide is melittin, a fraction from the venom of the bee. This study aimed to evaluate the antibacterial and antibiofilm activities of melittin and its association with oxacillin (mel+oxa) against MRSA isolates, and to investigate the mechanisms of action of the treatments on MRSA.
View Article and Find Full Text PDFAims: The antibacterial activity of red propolis extract (RPE) and brown propolis extracts (BPE) and the synergistic effect of RPE with cefoxitin (CEFO), imipenem (IMI), and ertapenem (ERTA) was evaluated in vitro against methicillin-resistant Staphylococcus aureus (MRSA) strains.
Methods And Results: MRSA ATCC 33591, community-associated (CA-MRSA) USA300, and four clinical isolates were used. A broth microdilution assay was performed to obtain inhibitory and bactericidal concentrations of BPE, RPE, CEFO, IMI, and ERTA.
Article Synopsis
- Caseous lymphadenitis, caused by Corynebacterium pseudotuberculosis, primarily affects small ruminants and has limited zoonotic potential, making treatment options limited and often ineffective due to complications.
- Researchers tested the antibacterial effects of 2',3'-dideoxiadenosine (ddATP) on C. pseudotuberculosis, determining its minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) which showed some effectiveness, particularly with the ATCC® 19,410 strain.
- The study suggests that combining ddATP with penicillin may offer a new treatment strategy for infections caused by C. pseudotuberculosis, providing insights into alternative therapeutic approaches.
Inhibitory activities of propolis, nisin, melittin and essential oil compounds on and .
J Venom Anim Toxins Incl Trop Dis
September 2022
Background: Natural products represent important sources of antimicrobial compounds. Propolis and compounds from essential oils comprise good examples of such substances because of their inhibitory effects on bacterial spores, including bee pathogens.
Methods: Ethanol extracts of propolis (EEP) from were prepared using different methods: double ultrasonication, double maceration and maceration associated with ultrasonication.
Article Synopsis
- - The study tested the antibacterial effects of apitoxin (bee venom) and melittin (an antimicrobial peptide) against both planktonic and biofilm forms of MRSA (methicillin-resistant Staphylococcus aureus), including various clinical isolates.
- - Results indicated that the minimum inhibitory concentrations (MICs) were 7.2 μg/mL for apitoxin and 6.7 μg/mL for melittin, with corresponding minimum bactericidal concentrations (MBCs) of 28.7 μg/mL and 26 μg/mL.
- - Both substances showed bactericidal synergism when combined with oxacillin, demonstrated cell damage in bacteria via transmission electron microscopy
Article Synopsis
- The study focused on how methicillin-resistant Staphylococcus aureus (MRSA) reacts to a combination of nisin and oxacillin, identifying significant changes in 85 of 135 proteins when compared to untreated bacteria.
- The combination treatment increased the expression of proteins related to antibiotic resistance and protein synthesis, while decreasing those linked to stress responses and energy metabolism, indicating a shift in bacterial mechanisms.
- Additionally, the treatment caused noticeable damage to the bacterial cell structure, leading to cell lysis and death, demonstrating that the combination of these antimicrobials could be an effective therapeutic strategy against resistant bacteria.
Article Synopsis
- The study investigates the efficacy of cinnamaldehyde, a natural product, against Staphylococcus epidermidis, particularly focusing on its ability to inhibit bacterial growth and biofilm formation in the context of rising antibiotic resistance.
- Results showed that cinnamaldehyde has a minimum inhibitory concentration (MIC) of 300 to 500 μg/mL and can significantly reduce biofilm formation, with higher concentrations needed to target established biofilms.
- Additionally, the combination of cinnamaldehyde with the antibiotic linezolid demonstrated a potent bactericidal effect, indicating its potential as a new antimicrobial agent.
Short communication: Inhibitory activities of the lantibiotic nisin combined with phenolic compounds against Staphylococcus aureus and Listeria monocytogenes in cow milk.
J Dairy Sci
March 2016
We aimed to investigate the antibacterial activities of carvacrol, thymol, eugenol, cinnamaldehyde, and lantibiotic nisin against standard bacterial strains of the milk pathogens Staphylococcus aureus ATCC 25923 and Listeria monocytogenes ATCC 15313 in cow milk. The minimum inhibitory concentrations (MIC) of these substances were recorded. The synergistic effects were also assessed in culture medium (time kill curve) and in a food model (cow milk) during the storage period (4 °C for 6 d) after inoculation with S.
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