Reconceptualizing cannabis use risks in the context of health and social inequities: Insights from a qualitative study with young people in Canada.

Background: Cannabis became legal in Canada in 2018. Since then, calls for research to evaluate the impact of legalization on youth have been at the forefront of public and academic discussions. Research addressing these calls has largely focused on issues of risk and harm, with limited attention to the role of social context in shaping youth cannabis use.

Unravelling the broader complexity of IL-6 involvement in health and disease.

The classification of interleukin-6 (IL-6) as a pro-inflammatory cytokine undervalues the biological impact of this cytokine in health and disease. With broad activities affecting the immune system, tissue homeostasis and metabolic processes, IL-6 displays complex biology. The significance of these involvements has become increasingly important in clinical settings where IL-6 is identified as a prominent target for therapy.

Effects of calcitriol on calbindins gene expression and lipid peroxidation in human placenta.

Pregnancy is associated with increased maternal calcitriol levels and placenta is an extrarenal source of this hormone. Calbindin-D9k and calbindin-D28k are vitamin D-dependent. Since calbindin-D28k has been considered as an antioxidant factor, the aim of the present work was to investigate the effects of calcitriol on calbindins gene expression and lipid peroxidation in cultured syncytiotrophoblast cells obtained from healthy human placentas.