Publications by authors named "Ana Fernandez de Valderrama"
Ustekinumab is an effective therapy for adult Crohn's disease (CD), but data in paediatric CD patients are scarce. The aim of the study was to describe the real-life effectiveness and safety of ustekinumab in paediatric CD. This is a multicentre review of children with Crohn's disease treated with ustekinumab.
View Article and Find Full Text PDFProton Pump Inhibitor Therapy in Pediatric Eosinophilic Esophagitis: Predictive Factors and Long-Term Step-Down Efficacy.
Carolina Gutiérrez-Junquera Sonia Fernández-Fernández Gloria Domínguez-Ortega Víctor Vila Miravet Roger García-Puig Ana Fernández de Valderrama
J Pediatr Gastroenterol Nutr
February 2023
Article Synopsis
- This study evaluated how effective proton pump inhibitors (PPIs) are for treating children with eosinophilic esophagitis (EoE) in both the short- and long-term, using a step-down therapy approach.
- Results showed that after initial treatment, over half of the children achieved significant histological and clinical remission, with normal endoscopic appearances linked to better outcomes, while those with fibrostenotic phenotypes averaged poorer responses.
- Long-term follow-up indicated that most children could maintain remission with reduced medication, and those starting with complete histological remission had a higher chance of sustained success; adverse effects were minimal.
Article Synopsis
- - Eosinophilic oesophagitis is a chronic immune-mediated disorder leading to oesophageal inflammation and dysfunction, particularly affecting males and those with allergies, and presenting different symptoms at varying ages.
- - Diagnosis involves identifying symptoms and finding at least 15 eosinophils per high power field in the oesophagus while excluding other causes, and without treatment, the disease can worsen in adults.
- - Treatment options include proton pump inhibitors, dietary changes, and corticosteroids, with an emphasis on maintaining therapy and using histological assessments to gauge treatment effectiveness; this document aims to guide the management of the condition based on updated guidelines.