Publications by authors named "Ana Ferle-Vidovic"
Radioprotective and antitumor activity evaluation of newly synthesized adamantyl tenocyclidines.
Cancer Biother Radiopharm
October 2003
Article Synopsis
- Several new adamantyl derivatives of thienyl phencyclidine (TCP) were synthesized and tested for biological activity, focusing on their effects on human tumor cells and nonmalignant mouse fibroblasts.
- These derivatives, particularly TAMORPH, showed reduced toxicity and improved radioprotective properties compared to TCP, promoting greater apoptotic death in cancer cells.
- In vivo studies on C3Hf mice indicated that these derivatives provided enhanced radioprotection while being less toxic than the original TCP compound.