Publications by authors named "Ana Elisa Ribeiro Orsi"
Article Synopsis
- Recent advancements in creating human blastoids from naive pluripotent stem cells have improved the efficiency and quantity of these models for studying early human development and implantation.
- The new protocol allowed researchers to conduct proteomics analysis, revealing specific phosphosite signatures important for the signaling processes in human blastoids.
- Additionally, findings indicated that endometrial stromal cells support trophoblast cell survival and growth, while single-cell RNA sequencing helped identify similarities in gene expression between blastoids and blastocysts.
The third and fourth weeks of gestation in primates are marked by several developmental milestones, including gastrulation and the formation of organ primordia. However, our understanding of this period is limited due to restricted access to in vivo embryos. To address this gap, we developed an embedded 3D culture system that allows for the extended ex utero culture of cynomolgus monkey embryos for up to 25 days post-fertilization.
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