Publications by authors named "Ana E Santo"
Acute myeloid leukemia (AML) treated with intensive chemotherapy carries a high risk of severe infection. The development of reliable assessment tools to promptly identify patients at risk of developing critical illness is essential to prevent delays in intensive care unit (ICU) admission. This study evaluated the accuracy of quick Sequential Organ Failure Assessment (qSOFA) score, National Early Warning Score (NEWS), and NEWS2 score in predicting ICU admission and sepsis-related mortality in this population.
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- * Research shows that GSL synthesis is crucial for osteoclast activation in MM, and myeloma cells produce GSLs that enhance this activation, particularly GM3.
- * Inhibiting GSL synthesis with drugs like NB-DNJ can prevent OC development, reduce bone damage in MM cases, and shows promise for treating osteolytic bone diseases.