Publications by authors named "Ana E Jenike"
Article Synopsis
- The study investigates the evolution of specialized cell types, particularly focusing on microRNAs like Mir-126, which may be essential for understanding cellular specialization.
- Researchers propose that Mir-126 originated in a common ancestor of vertebrates and tunicates, predating the evolution of endothelial cells, and has undergone significant changes through duplications and losses over time.
- By examining the expression of Mir-126 in the tunicate Ciona robusta, the study demonstrates that its expression shift from proto-endothelial amoebocytes to endothelial cells in vertebrates supports the idea that microRNAs can drive cell-type evolution.
Cell-specific microRNA (miRNA) expression estimates are important in characterizing the localization of miRNA signaling within tissues. Much of these data are obtained from cultured cells, a process known to significantly alter miRNA expression levels. Thus, our knowledge of in vivo cell miRNA expression estimates is poor.
View Article and Find Full Text PDFmiRNA-21 is among the most abundant and highly conserved microRNAs (miRNAs) recognized. It is expressed in essentially all cells where it performs vital regulatory roles in health and disease. It is also frequently claimed to be a biomarker of diseases such as cancer and heart disease in bodily-fluid based miRNA studies.
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