Publications by authors named "Ana Dugic"

Background And Aims: Patients with alcohol-related liver disease (ALD) might be at increased risk of acute pancreatitis (AP), but large-scale data are lacking.

Methods: Population-based cohort study using data from the Swedish National Patient Register on 37,062 patients with ALD from 1969 to 2020. Patients were matched to ≤10 general population comparators (n = 352,931).

View Article and Find Full Text PDF

Objective: Ampullary neoplastic lesions can be resected by endoscopic papillectomy (EP) or transduodenal surgical ampullectomy (TSA) while pancreaticoduodenectomy is reserved for more advanced lesions. We present the largest retrospective comparative study analysing EP and TSA.

Design: Of all patients in the database, lesions with prior interventions, benign histology advanced malignancy (T2 and more), patients with hereditary syndromes and those undergoing pancreatoduodenectomy were excluded.

View Article and Find Full Text PDF

Background: Endoscopic retrograde cholangiopancreatography (ERCP) still has a relatively high complication rate, underscoring the importance of high-quality training. Despite existing guidelines, real-world data on training conditions remain limited. This pan-European survey aims to systematically explore the perceptions surrounding ERCP training.

View Article and Find Full Text PDF
Article Synopsis
  • - Pain is a major issue for about 70% of chronic pancreatitis patients, but the nature of this pain varies among individuals, complicating treatment approaches.
  • - The INPAIN study will analyze 400 chronic pancreatitis patients and include a control group, using a specialized testing panel over four years to identify pain profiles and predict treatment responses.
  • - This research aims to create a bedside tool that personalizes treatment strategies for chronic pancreatitis pain, potentially leading to better patient outcomes and reduced side effects.
View Article and Find Full Text PDF

Background And Aims: Ampullary lesions (ALs) of the minor duodenal papilla are extremely rare. Endoscopic papillectomy (EP) is a routinely used treatment for AL of the major duodenal papilla, but the role of EP for minor AL has not been accurately studied.

Methods: We identified 20 patients with ALs of minor duodenal papilla in the multicentric database from the Endoscopic Papillectomy vs Surgical Ampullectomy vs Pancreatitcoduodenectomy for Ampullary Neoplasm study, which included 1422 EPs.

View Article and Find Full Text PDF

Introduction: Most patients with chronic pancreatitis (CP) develop pancreatic exocrine insufficiency (PEI) over the course of the disease. PEI may lead to hyperoxaluria and development of urinary oxalate stones. It has been postulated that the patients with CP may be at increased risk of kidney stone formation, but the data is scarce.

View Article and Find Full Text PDF

Objective: To analyze the proportion of diabetes among all hospitalized cases in Germany between 2015 and 2020.

Methods: Using the nationwide Diagnosis-Related-Groups statistics, we identified among all inpatient cases aged ≥ 20 years all types of diabetes in the main or secondary diagnoses based on ICD-10 codes, as well all COVID-19 diagnoses for 2020.

Results: From 2015 to 2019, the proportion of cases with diabetes among all hospitalizations increased from 18.

View Article and Find Full Text PDF

Background: Familial adenomatous polyposis (FAP) is a rare inherited syndrome that predisposes the patient to cancer. Treatment of FAP-related ampullary lesions is challenging and the role of endoscopic papillectomy has not been elucidated. We retrospectively analyzed the outcomes of endoscopic papillectomy in matched cohorts of FAP-related and sporadic ampullary lesions (SALs).

View Article and Find Full Text PDF

Background: Ampullary lesions are rare and can be locally treated either with endoscopic papillectomy or transduodenal surgical ampullectomy. Management of local recurrence after a first-line treatment has been poorly studied.

Methods: Patients with a local recurrence of an ampullary lesion initially treated with endoscopic papillectomy or transduodenal surgical ampullectomy were retrospectively included from a multi-institutional database (58 centers) between 2005 and 2018.

View Article and Find Full Text PDF

Background: Post-pancreatitis diabetes mellitus (PPDM) is a common consequence of chronic pancreatitis (CP). We aimed to determine the incidence and predictors of PPDM after CP onset, as well as complications and antidiabetic therapy requirements, in a high-volume tertiary center.

Methods: We did a cohort study with retrospectively collected data from patients with definite CP seen at the Karolinska University Hospital between January 1999 and December 2020.

View Article and Find Full Text PDF
Article Synopsis
  • Chronic pancreatitis (CP) can present as either painful or painless, with a notable percentage (26.9%) of patients experiencing painless CP.
  • Painless CP patients are generally older at the time of diagnosis (61.7 years) compared to those with painful CP (52.5 years) and have a lower occurrence of alcoholic causes.
  • Both groups show similar rates of diabetes and pancreatic exocrine insufficiency, highlighting the need for regular monitoring of all CP patients, regardless of pain status.
View Article and Find Full Text PDF

(1) Background: Patients with new-onset diabetes (NOD) are at risk of pancreatic ductal adenocarcinoma (PDAC), but the most relevant additional risk factors and clinical characteristics are not well established. (2) Objectives: To compare the risk for PDAC in NOD patients to persons without diabetes. Identify risk factors of PDAC among NOD patients.

View Article and Find Full Text PDF

Autoimmune pancreatitis (AIP) is a rare etiological type of chronic pancreatitis. The clinical and radiological presentation of AIP often resembles that of pancreatic cancer. Identifying non-invasive markers for their early distinction is of utmost importance to avoid unnecessary surgery or a delay in steroid therapy.

View Article and Find Full Text PDF

Summary: Drinking fruit juice is an increasingly popular health trend, as it is widely perceived as a source of vitamins and nutrients. However, high fructose load in fruit beverages can have harmful metabolic effects. When consumed in high amounts, fructose is linked with hypertriglyceridemia, fatty liver and insulin resistance.

View Article and Find Full Text PDF