Publications by authors named "Ana Dominguez-Mayoral"
Article Synopsis
- NOTCH3cys variants are common and linked to various small vessel diseases, including early-onset stroke and dementia, but there is no comprehensive staging system to assess their severity.
- A cohort study created and validated a simple staging system for NOTCH3-SVD by analyzing data from several international cohorts and the UK Biobank, focusing on the impact of these variants on CVD outcomes and cognition.
- The new system includes 9 disease stages, aiding in understanding the relationship between stages and clinical outcomes like ischemic strokes, cognitive function, and brain damage.
Background: The evolution of ischemic stroke is different accordin'g to sex and is one of the main causes of death in women. Previous studies have shown that women are less likely to receive acute treatment, and stroke center type is an important predictor of door-to-needle times. We investigated whether women are attended in a similar way to men in the telestroke network with specialized stroke physicians.
View Article and Find Full Text PDF: Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a hereditary small vessel disease leading to significant morbidity and mortality. Despite advances in genetic diagnosis, the underlying pathophysiology remains incompletely understood. Proteomic studies offer insights into disease mechanisms by identifying altered protein expression patterns.
View Article and Find Full Text PDFObjective: The modified Centers for Disease Control and Prevention (mCDC) criteria have been proposed for diagnosing and managing stroke-associated pneumonia (SAP). The objective was to investigate the impact of SAP on stroke outcome depending on whether or not it conforms to mCDC criteria. Our secondary objective was to identify the responsible factors for antibiotic initiation in stroke patients.
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- Researchers analyzed ischaemic stroke (IS) cases that occurred within eight days of COVID-19 onset to determine if they have a unique genetic background compared to other stroke types.
- Using a method called SUPERGNOVA, they identified specific genomic regions related to large artery atherosclerosis (LAA) and cardioembolic stroke (CES) from a cohort of 73 IS-COV patients and 701 control subjects.
- The study found four genetic loci associated with CES and significant polygenic risk scores for LAA, suggesting IS-COV patients may share genetic traits with these stroke subtypes; more research is needed to see if these traits are specific to viral infection or common in the general population.
The 2020-21 West Nile Virus (WNV) outbreak in Andalusia, Spain, was the largest reported in the country, with eight cases of West Nile Neuroinvasive Disease (WNND) diagnosed in a tertiary hospital. Diagnosis of WNND is based on detecting WNV RNA, viral isolation, or demonstrating a specific immune response against the virus, with additional tests used to support the diagnosis. Treatment remains supportive, with variable outcomes.
View Article and Find Full Text PDFIntroduction: Cerebral amyloid angiopathy (CAA) is characterized by the accumulation of amyloid-β (Aβ) in brain vessels and is a main cause of lobar intracerebral hemorrhage (ICH) in the elderly. CAA is associated with magnetic resonance imaging (MRI) markers of small vessel disease (SVD). Since Aβ is also accumulated in Alzheimer's disease (AD) in the brain parenchyma, we aimed to study if several single nucleotide polymorphisms (SNPs) previously associated with AD were also associated with CAA pathology.
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- Neurologic impairment can last for months after severe COVID-19 infection due to ongoing inflammation.
- A study analyzed cognitive functions in 152 patients recovering from severe SARS-CoV-2 infection, finding significant issues with memory, executive functions, and attention, alongside elevated anxiety and depression rates.
- The study also identified increased levels of certain plasma biomarkers in these patients, raising concerns about potential long-term cognitive effects or the risk of neurodegenerative diseases.
Objective: Spain's so-called Stroke Belt is an area with high prevalence of vascular disease. We aimed to determine the prevalence of undetected obstructive sleep apnea-hypopnea syndrome (OSAHS) among patients with acute ischemic stroke (AIS) in southern Spain.
Methods: We conducted a cross-sectional study at the Virgen Macarena University Hospital Stroke Unit during 2018 to 2019.
A 43 year-old male presented with a relapsing and progressive systemic inflammatory disorder with central nervous system (CNS) involvement. After a two years follow up, he was diagnosed with hemophagocytic lymphohistiocytosis (HLH), based on clinical, laboratory and radiological findings. Treatment was started with anakinra, a recombinant humanised interleukin-1 (IL-1) receptor antagonist.
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- Perinatal and pediatric neurovascular disorders significantly impact long-term health, making early diagnosis and treatment vital for preventing brain damage.
- Current diagnostic methods like physical exams and neuroimaging have limitations, leading to increased interest in noninvasive biomarkers for better monitoring of at-risk children.
- The review highlights potential biomarkers like S-100B and GFAP for diagnosing neurovascular diseases, suggesting they could enhance treatment classification and response monitoring when combined with new discoveries.
Background: Stroke is an abrupt interruption of brain circulation that constitutes a neurological emergency. Aphasia is a language disorder caused by stroke. It can affect patients' reading, writing, comprehension and expression.
View Article and Find Full Text PDFObjectives: The detection of cervical arterial dissection (CAD) has been rising in recent years owing to advanced imaging techniques. The aim of this study was to explore whether wide implementation of endovascular treatment for ischemic stroke has an impact on the diagnosis of CAD.
Methods: We included all patients with CAD diagnosed at two university hospitals in Seville, Spain from January 2015 to December 2017.