Publications by authors named "Ana Cristina Racca"
Article Synopsis
- StarD7 is part of the START protein family, involved in lipid transport and cellular signaling, and its isoforms play different roles in cell function.
- Silencing StarD7 reduces the expression of key proteins (Cx43, integrin β1, and p-ERK1/2) in non-cancerous migrating cells and disrupts their cellular structures.
- Restoring Cx43 levels can regain cell migration abilities, while expressing the StarD7.II isoform enhances migration and the levels of the aforementioned proteins, indicating StarD7's role in cell migration is linked to an ERK1/2/Cx43 pathway.
Tumor cells require high rates of lipid synthesis to support membrane biogenesis for their exacerbated growth. The only two proteins known that activate phospholipid synthesis are Fra-1 and c-Fos, two members of the AP-1 family of transcription factors. These proteins that are overexpressed in human breast malignant tumors increase the rate of phospholipid synthesis at the endoplasmic reticulum through a mechanism independent of their nuclear function.
View Article and Find Full Text PDFCell-cell fusion is an essential event during life. Throughout human pregnancy, the syncytiotrophoblast (STB) layer of the placenta is formed by continuous fusion of the underlying villous cytotrophoblasts, thus maintaining placental functionality. Defects in this process are associated with pathologies like pre-eclampsia and intrauterine growth restriction.
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