Association between exposure to air pollutants and hospitalization for SARS-Cov-2: an ecological time-series study.

Background: Exposure to air pollutants and illness by severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection can cause serious pulmonary impairment.

Objective: To identify a possible association between exposure to air pollutants and hospitalizations due to SARS-Cov-2.

Design And Setting: Ecological time-series study carried out in Taubaté, Tremembé, and Pindamonhangaba in 2020 and 2021.

Fine particulate matter and ischemic heart diseases inrelation to sex. An ecological time series study.

Background: Exposure to some air pollutants is associated with cardiovascular diseases. The objective of this study was to quantify the effect of exposure to fine particulate matter in hospitalizations due to ischemic heart disease and the costs to the healthcare system.

Design And Setting: Time-series ecological study conducted in Taubaté, Brazil.

Coarse particles and hospital admissions due to respiratory diseases in children. An ecological time series study.

Background: Exposure to particulate matter (PM) is associated with hospitalizations due to respiratory diseases among children.

Design And Setting: An ecological time series study was carried out to identify the role of coarse fractions of particulate matter (PM10-2.5) in hospitalizations among children up to 10 years of age, in Piracicaba (SP) in the year 2015.

Cytotoxic and genotoxic assessment of surface water from São Paulo State, Brazil, during the rainy and dry seasons.

The aim of this study was to determine if the cytotoxic and genotoxic responses of Allium cepa are effective biomarkers of harmful effects caused by polluted river water and if changes in the responses reflect seasonality in the harmful effects. Samples were collected in the dry season (August 2011 and 2012) and rainy season (February 2012 and 2013) at sampling points on the Jaguari River and the Ribeirão Lavapés, in Brazil. Allium cepa bulbs were exposed to the samples, to positive controls (15 µg/L methyl methanesulfonate), and to negative controls (tap water).

[Fine particulate matter estimated by mathematical model and hospitalizations for pneumonia and asthma in children].

Objective:: To estimate the association between exposure to fine particulate matter with an aerodynamic diameter <2.5 microns (PM) and hospitalizations for pneumonia and asthma in children.

Methods:: An ecological study of time series was performed, with daily indicators of hospitalization for pneumonia and asthma in children up to 10 years of age, living in Taubaté (SP) and estimated concentrations of PM, between August 2011 and July 2012.

[Association between exposure to particulate matter and hospital admissions for respiratory disease in children].

The aim of this study was to estimate the association between exposure to particulate matter less than 2.5 microns in diameter and hospitalization for respiratory disease. It was an ecological time series study with daily indicators of hospitalization for respiratory diseases in children up to 10 years old, living in Piracicaba, SP, Southeastern Brazil, between August 1, 2011 and July 31, 2012.

Genetic alterations in benign lesions: chronic gastritis and gastric ulcer.

Aim: To investigate the occurrence of chromosome 3, 7, 8, 9, and 17 aneuploidies, TP53 gene deletion and p53 protein expression in chronic gastritis, atrophic gastritis and gastric ulcer, and their association with H pylori infection.

Methods: Gastric biopsies from normal mucosa (NM, n=10), chronic gastritis (CG, n=38), atrophic gastritis (CAG, n=13) and gastric ulcer (GU, n=21) were studied using fluorescence in situ hybridization (FISH) and immunohistochemical assay. A modified Giemsa staining technique and PCR were used to detect H pylori.

Aneuploidies, deletion, and overexpression of TP53 gene in intestinal metaplasia of patients without gastric cancer.

Gastric carcinogenesis is attributable to interacting environmental and genetic factors, through a sequence of events including intestinal metaplasia. Using a fluorescence in situ hybridization technique, we investigated the occurrence of aneuploidies of chromosomes 3, 7, 8, 9, and 17, TP53 gene deletion, and expression of p53 in 21 intestinal metaplasia (IM) samples from cancer-free patients and in 20 gastric adenocarcinoma samples. Aneuploidies were found in 71% (15/21) of the IM samples.

[Genetics and environmental factors in gastric carcinogenesis].

Background: Gastric cancer is considered to be the second most common cancer worldwide. Carcinogenesis of the stomach is a multi-stage process. The progression from normal epithelial to tumor cells may involve at least five stages: superficial gastritis, chronic atrophic gastritis, intestinal metaplasia, dysplasia and carcinoma.