Publications by authors named "Ana Claudia de Freitas Oliveira"
Thioridazine inhibits gene expression control of the cell wall signaling pathway (CWI) in the human pathogenic fungus Paracoccidioides brasiliensis.
Mol Genet Genomics
June 2016
Article Synopsis
- Paracoccidioides brasiliensis is a fungus causing paracoccidioidomycosis (PCM), a prevalent systemic infection in Latin America that often requires long-term treatment and has a high relapse rate.
- Recent research found that thioridazine, a phenothiazine derivative, can effectively inhibit the growth of this fungus in laboratory settings, affecting about 1800 genes involved in its cellular processes.
- The study highlights that thioridazine disrupts the cell wall integrity signaling of the fungus, which could lead to new treatment strategies for fungal infections by targeting the production of essential cell wall components.
Strains of Xylella fastidiosa constitute a complex group of bacteria that develop within the xylem of many plant hosts, causing diseases of significant economic importance, such as Pierce's disease in North American grapevines and citrus variegated chlorosis in Brazil. X. fastidiosa has also been obtained from other host plants, in direct correlation with the development of diseases, as in the case of coffee leaf scorch (CLS)--a disease with potential to cause severe economic losses to the Brazilian coffee industry.
View Article and Find Full Text PDFParacoccidioides brasiliensis is a thermodimorphic fungus associated with paracoccidioidomycosis (PCM), the most common systemic mycosis in Latin America. The infection is initiated by inhalation of environmentally dispersed conidia produced by the saprophytic phase of the fungus. In the lungs, P.
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