Publications by authors named "Ana Claudia Souza Rodrigues"
Article Synopsis
- * Researchers examined various resistance genes, finding high prevalence rates of KPC (88.9%), SHV (73.5%), TEM (72.2%), and CTX-M (43.9%), and discovered new sequence types that had not been previously identified in the country.
- * The study also revealed that the same bacterial clone is present across different hospitals in the same region, indicating the spread of multidrug-resistant infections.
Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases.
Yasmin Coelho Patrial Luma Petri Tortorelli Ana Claudia Souza Rodrigues Ivson Cassiano de Oliveira Santos Cláudia Elizabeth Volpe-Chaves Marilene Rodrigues Chang
Rev Inst Med Trop Sao Paulo
February 2020
Article Synopsis
- Nosocomial infections from carbapenem-resistant Klebsiella pneumoniae (CRKP) lead to high mortality rates, particularly in neurosurgery patients, with limited literature on CRKP-related meningitis.
- This study reports two cases of CRKP meningitis following neurosurgery, highlighting multidrug-resistant strains identified using the Vitek Compact System and genetic typing revealing two novel clones (ST1298 and ST2687).
- Treatment involved intrathecal polymyxin, and the authors recommend this approach for managing meningitis caused by multidrug-resistant K. pneumoniae.
Non-clonal occurrence of pmrB mutations associated with polymyxin resistance in carbapenem-resistant Klebsiella pneumoniae in Brazil.
Ana Claudia Souza Rodrigues Ivson Cassiano de Oliveira Santos Caroline Conci Campos Isadora Nascimento Rezende Yanara Miranda Ferreira Marilene Rodrigues Chang
Mem Inst Oswaldo Cruz
July 2019
Article Synopsis
- Polymyxins are used as a last-resort treatment for infections caused by resistant Gram-negative bacteria, specifically targeting Klebsiella pneumoniae in this study.
- The study analyzed 97 strains of K. pneumoniae for resistance mechanisms, identifying key β-lactamase genes and mutations in the pmrB gene associated with polymyxin resistance.
- Findings show high prevalence of specific resistance genes and confirm that mutations in pmrB, particularly T157P, are significant in developing resistance among the K. pneumoniae strains in Brazilian public hospitals.
Article Synopsis
- Melioidosis, caused by Burkholderia pseudomallei, is an emerging infectious disease in Brazil with high morbidity and mortality rates; only 28 cases were reported until 2015, mainly concentrated in the Northwest region, with the Midwest previously unreported.
- A 42-year-old man presented with respiratory symptoms and was diagnosed with the first case of pneumonia with sepsis due to B. pseudomallei in Mato Grosso do Sul, highlighting a new occurrence of this disease in the Midwest.
- The patient was successfully treated with antibiotics (trimethoprim/sulfamethoxazole and meropenem) and survived, underscoring the need to recognize melioidosis in community-acquired infections, especially
The emergence of β-lactamase-producing Enterobacteriaceae in the last few decades has become major challenge faced by hospitals. In this study, isolates of Klebsiella pneumoniae carbapenemase-2 (KPC-2)-producing K. pneumoniae from a tertiary hospital in Mato Grosso do Sul, Brazil, were characterized.
View Article and Find Full Text PDFInfection by Pseudomonas aeruginosa has spread worldwide, with limited options for treatment. The purpose of this study was to investigate metallo-β-lactamase-producing P. aeruginosa strains and compare their genetic profile using samples collected from patients in intensive care units.
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