Publications by authors named "Ana Claudia Rodrigues da Silva"

Introduction: This study evaluated the effects of cigarette smoke inhalation (CSI) on apical periodontitis (AP) induced in rats by histometric, immunohistochemical, and microtomographic analysis.

Methods: A total of 32 male Wistar rats were divided into 4 experimental groups (n = 8): control, CSI, AP, and CSI + AP. Rats in the CSI and CSI + AP groups inhaled cigarette smoke by remaining inside a smoking chamber for 8 minutes 3 times a day for 50 days.

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Biocompatibility and biomineralization of root canal dressings are important requirements for periapical healing. This study evaluated the inflammatory response, biomineralization and tissue repair by collagen fiber maturation in the subcutaneous tissue of rats. Eighteen Wistar rats ( = 6) received subcutaneous implants: calcium hydroxide + propylene glycol [CH+P], calcium hydroxide + propylene glycol + iodoform [CH+P+I], iodoform + carbowax [I+Cwax] and carbowax [Cwax].

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Objective: To evaluate the effects of cigarette smoke inhalation on the immune-inflammatory profile of experimental apical periodontitis in rats.

Methodology: In total, 32 male Wistar rats were divided into four groups (n = 8): AP-induced apical periodontitis; S-cigarette smoke inhalation; APS-induced AP and cigarette smoke inhalation; and C (control)-neither AP nor cigarette smoke inhalation. To induce cigarette smoke inhalation, the animals were kept in a chamber filled with tobacco smoke for 8 min thrice a day for 50 days.

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Article Synopsis
  • - The study assessed the biocompatibility, biomineralization, and antibacterial properties of different resinous endodontic sealers with calcium hydroxide over a period of 60 days using a rat model.
  • - Sealer 26 demonstrated the highest biomineralization and maturation of collagen fibers throughout the study, while inflammatory responses were generally mild after 60 days across all tested materials.
  • - Although all sealers displayed good biocompatibility and some antibacterial activity, they were less effective than chlorhexidine, with no significant antibacterial differences noted among the sealers themselves.
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has been associated with bacteremia, sepsis, and bacterial endocarditis and peri-implantitis. This microorganism can remain in the alveolus even after extraction of the root remnant. This study aimed to evaluate the corrosion on different surfaces of commercially pure titanium (Ti) grade 4 (Ticp-G4) as a function of the bacterial biofilm effect of .

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Schistosomiasis is caused by the parasite , which uses mollusks of the genus as intermediate hosts. In 2020, approximately 241 million people worldwide underwent treatment for schistosomiasis. For this reason, the World Health Organization encourages research on alternative molluskicides based on plant species.

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Aim: The aim of this study was to evaluate the effects of cigarette smoke inhalation (CSI) on inflammation, pro-inflammatory mediators and haematological parameters in rats with induced apical periodontitis (AP).

Methodology: Thirty-two 3-month-old male Wistar rats were divided into four experimental groups (n = 8): C-Control; S-rats with CSI; AP-rats with AP; and SAP-rats with CSI + AP. Animals in groups S and SAP inhaled cigarette smoke by remaining inside a smoking chamber for 8 min, three times daily, for 50 days.

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Snake bite envenoming is a serious public health issue, affecting thousands of people worldwide every year, especially in rural communities of tropical and subtropical countries. Injection of venom into victims may cause hemorrhaging, blood coagulation imbalance, inflammation, pain, edema, muscle necrosis, and eventually, death. The official validated treatment recommended by governments is the administration of antivenom that efficiently prevents morbidity and mortality.

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Article Synopsis
  • Snakebite envenoming is a serious health issue and classified as a neglected tropical disease by the WHO since 2017.
  • This study examined the effectiveness of ten 1,2,3-triazole derivatives (AM001 to AM010) in inhibiting various toxic activities of snake venom, including coagulant and lethal effects.
  • The derivatives showed promise in reducing venom toxicity without being harmful themselves, particularly AM006 and AM010, suggesting they could be helpful in treating local effects of snakebites.
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Objective: To analyze the lack of 5-lipoxygenase (5LO) on dental socket healing and post-natal phenotype of intramembranous and endochondral bones.

Design: Wild type (WT) 129/SvEv (n = 20) and 5LO knockout (5LOKO) (n = 20) male mice underwent tooth extraction of the upper right incisor and were euthanized after 7, 14, and 30 day time points for the evaluation of dental socket healing and histological phenotyping of intramembranous (IM) and endochondral (EC) bones. Microscopic analysis of alveolar sockets included histopathological description, histomorphometry, and immunohistochemistry for 5LO, cyclooxygenase 2 (COX2), and tartrate resistant acid phosphatase (TRAP).

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  • - Snake envenomation is a significant global health concern, and current antivenoms often fail to effectively neutralize local toxins.
  • - A study focused on the plant Schwartzia brasiliensis, which showed promise in inhibiting various toxic effects of Bothrops jararaca and B. jararacussu venoms, including coagulant and hemolytic activities.
  • - The extract from S. brasiliensis was found to be non-toxic to mice and red blood cells, suggesting its potential as an alternative treatment to enhance current antivenom therapy for snakebites.
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Knowledge about the action of immune system in the recognition of biomaterials has been extremely helpful when it comes about understanding host response and biomaterials' fate in human body. This study aimed to investigate inflammatory response and macrophage polarization during bone healing process of rat's calvaria critical defects using different bone materials in order to evaluate their influence on bone repair and on the quality of the newly formed bone tissue. Eighty male albinus Wistar rats underwent surgical procedure for the confectioning of a 5-mm diameter bone defect in their right parietal bone, and divided in four groups (n = 20 each), according the biomaterial: AG - Control, particulate intramembranous autogenous bone graft, HA/TCP - particulate biphasic calcium phosphate with HA/TCP (60/40), DBB - particulate deproteinized bovine bone, VC - particulate bioactive vitroceramic.

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  • * A study examined the effectiveness of a polysaccharide extracted from green marine alga (Go3) in counteracting the toxic effects of certain snake venoms through various in vitro and in vivo tests.
  • * Results showed that Go3 effectively inhibited multiple harmful activities of the venoms and demonstrated potential as an alternative antivenom, particularly showing greater efficacy against one specific type of venom.
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Snakebite is a serious occupational hazard affecting mainly rural populations of tropical and subtropical developing countries. Lachesis muta (Bushmaster) bites are extremely serious but are rarely reported in the literature. Bushmaster envenomings are characterized by intense local pain, edema, neurotoxicity, hypotension, local hemorrhage, and dramatic systemic alterations.

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In Brazil, snakebites are a public health problem and accidents caused by Lachesis muta have the highest mortality index. Envenomation by L. muta is characterized by systemic (hypotension, bleeding and renal failure) and local effects (necrosis, pain and edema).

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