[Celecoxib in NSAID-induced cutaneous and respiratory adverse reactions].

Background And Objective: Inhibition of COX-1 appears to be a key event in most non-steroidal anti-inflammatory drugs (NSAIDs)-induced adverse reactions. We evaluated celecoxib tolerance, a highly specific COX-2 inhibitor, in NSAIDs-sensitive patients.

Patients And Method: Intolerant patients were challenged in a single-blind study with placebo and celecoxib (increasing doses up to 400 mg).