Protective effects of a chemically characterized extract from leaves on acetaminophen-induced liver injury.

Distinct parts of Swartz. (Solanaceae) are popularly used for a variety of therapeutic purposes. This study determined the phytochemical composition of a phenolic fraction of leaf aqueous extract and investigated its antioxidant and liver-protective properties.

Chemical profile, liver protective effects and analgesic properties of a Solanum paniculatum leaf extract.

Background/aim: Solanum paniculatum L. (Solanaceae) is a plant native to South America where it is used in traditional medicine for different therapeutic indications. This study evaluated the chemical composition and the hepatoprotective and analgesic activities of S.

Study on the developmental toxicity of β-ionone in the rat.

β-ionone (BIO) is used in fragrances, toiletries and non-cosmetic products, and as a flavor food additive. Notwithstanding the widespread human exposure, there are limited data on the reproductive toxicity of BIO. This study evaluated the developmental toxicity of BIO (0, 125, 250, 500 and 1000 mg/kg body weight/day) given orally to rats on days 6-15 of gestation (GD6-15).

Acute toxicity, cytotoxicity, genotoxicity and antigenotoxic effects of a cellulosic exopolysaccharide obtained from sugarcane molasses.

The acute toxicity, cytotoxicity, genotoxicity and antigenotoxic effects of BC were studied. Cytotoxicity of BC was evaluated in cultured C3A hepatoma cells (HepG2/C3A) using a lactate dehydrogenase (LDH) activity assay. Acute toxicity was tested in adults Wistar rats treated with a single dose of BC.

Modulation of expression and activity of cytochrome P450s and alteration of praziquantel kinetics during murine schistosomiasis.

In this study, we investigated the expression and activity of liver cytochrome P450s (CYPs) and praziquantel (PZQ) kinetics in mice infected with Schistosoma mansoni. Swiss Webster (SW) mice of both genders were infected (100 cercariae) on postnatal day 10 and killed on post-infection days (PIDs) 30 or 55. Non-infected mice of the same age and sex served as controls.

Serum concentrations of DDT and DDE among malaria control workers in the Amazon region.

Background: In Brazil, DDT was used to control malaria-transmitting mosquitoes from 1945 to 1997. Owing to concerns about the potential adverse health consequences of long-term exposures to DDT, workers of the National Foundation of Health (FNS) who had taken part in malaria control operations in the Amazon region were monitored for blood levels of DDT as well as for their health status between 1997 and 2001.

Objectives: To evaluate blood levels of DDT/DDE and elimination half-life (t(1/2)) of pp'-DDE in malaria control personnel.

Up- and down-modulation of liver cytochrome P450 activities and associated events in two murine malaria models.

Background: The mechanisms by which malaria up and down-regulates CYP activities are not understood yet. It is also unclear whether CYP activities are modulated during non-lethal malaria infections. This study was undertaken to evaluate the time course of CYP alterations in lethal (Plasmodium berghei ANKA) and non-lethal (Plasmodium chabaudi chabaudi) murine malaria.