Publications by authors named "Ana Caroline S Soares"
Article Synopsis
- Researchers studied how FGF2 expression in cumulus cells is regulated by FSH and substances from oocytes during in vitro maturation (IVM) in bovine models.
- The study found that FGF2, when added to IVM, sped up meiotic progress, made it harder to dissociate cumulus cells, and reduced cell death among those cells.
- This research highlights the role of oocytes in regulating FGF2 expression and suggests that FGF2 may enhance the survival and quality of cumulus cells during the maturation process.
In vivo, oocyte maturation is triggered by the ovulatory LH surge, whereas in vitro it is precociously induced when the cumulus-oocyte complex is removed from the follicle. Natriuretic peptide C (NPPC) delays germinal vesicle breakdown (GVBD) while increasing oocyte-cumulus communication during in vitro maturation (IVM) in cattle. In the present study we first tested the hypothesis that steroids secreted by the follicle (17β-oestradiol, progesterone and androstenedione) interact with NPPC to delay GVBD and to maintain oocyte-cumulus communication as assessed by transfer of a dye (Lucifer Yellow) from the oocyte to cumulus cells.
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