Chronobiological parameters as predictors of early treatment response in major depression.

Background: Alterations in circadian system organization have been related to major depressive disorder manifestations. This study aimed to evaluate chronobiological parameters, such as sleep, levels of 6-sulfatoxymelatonin, and others derived from actimetry as potential predictors of adequate treatment response in MDD.

Methods: 98 adult women with confirmed diagnosis of MDD were included.