Publications by Ana Carolina Mancanares

Publications by authors named "Ana Carolina Mancanares"

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Extracellular vesicles secreted by equine adipose mesenchymal stem cells preconditioned with transforming growth factor β-1 are enriched in anti-fibrotic miRNAs and inhibit the expression of fibrotic genes in an in vitro system of endometrial stromal cells fibrosis.

Yat Sen Wong Ana Carolina Mançanares Felipe Navarrete Pamela Poblete Lídice Mendez-Pérez

Vet Q

December 2024

Article Synopsis

Mare endometrosis is a problem that makes it hard for horses to have babies because it causes inflammation and damage to the reproductive system.
Scientists tested if special cells, called mesenchymal stem cells (MSCs), could help by using tiny packages they release called extracellular vesicles (EVs) with important information inside (miRNAs).
They found that treating MSCs with a specific signal (TGFβ-1) for only 4 hours made them better at fighting the damage, while longer treatment (24 hours) caused more problems, which could help create new treatments for mares with endometrial fibrosis.

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Short preconditioning with TGFβ of equine adipose tissue-derived mesenchymal stem cells predisposes towards an anti-fibrotic secretory phenotype: A possible tool for treatment of endometrosis in mares.

Yat Sen Wong Ana Carolina Mançanares Felipe Navarrete Pamela Poblete Lidice Mendez-Pérez

Theriogenology

September 2024

Endometrosis in mares is a disease resulting from chronic inflammation characterized by peri glandular fibrosis. There is no effective treatment so far, which opens the door for exploring the use of stem cells as a candidate. Transforming growth factor beta (TGFβ) is crucial for the establishment and progression of fibrosis in mare's endometrosis.