Publications by authors named "Ana Carolina Conchon Costa"
Roux-en-Y gastric bypass (RYGB) involves creating a small stomach pouch, bypassing part of the small intestine, and rerouting the digestive tract. These alterations can potentially change the drug exposure and response. Our primary aim was to assess the impact of RYGB on the pharmacokinetics of simvastatin lactone (SV) and its active metabolite, simvastatin hydroxy acid (SVA).
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- Scorpion envenomation cases in Santa Catarina, Brazil, particularly from the Tityus serrulatus species, have surged over 500% despite the species not being endemic to the area.
- A study from 2014 to 2021 analyzed 112 envenomation cases, primarily affecting men aged 20-39, occurring mostly in urban settings, with the majority classified as mild.
- The rise in cases suggests T. serrulatus may have been transported into urban areas where they thrive due to abundant food, shelter, and fewer natural predators.
The renal secretory clearance for organic cations (neurotransmitters, metabolism products and drugs) is mediated by transporters specifically expressed in the basolateral and apical plasma membrane domains of proximal tubule cells. Here, human organic cation transporter 2 (hOCT2) is the main transporter for organic cations in the basolateral membrane domain. In this study, we stably expressed hOCT2 in Madin-Darby Canine Kidney (MDCK) cells and cultivated these cells in the presence of an extracellular matrix to obtain three-dimensional (3D) structures (cysts).
View Article and Find Full Text PDFPopulation pharmacokinetics of gabapentin in patients with neuropathic pain: Lack of effect of diabetes or glycaemic control.
Br J Clin Pharmacol
April 2021
Article Synopsis
- Gabapentin (GBP) is commonly used to treat neuropathic pain, and this study aimed to understand how diabetes and blood sugar levels affect its pharmacokinetics in patients.
- The clinical trial involved 29 participants, analyzing GBP's absorption, distribution, and clearance through blood samples collected over 24 hours after a single dose.
- Results indicated that GBP’s drug disposition followed a specific model, and its clearance was linked to kidney function, showing no significant effects from hyperglycemia or diabetes on GBP distribution and excretion.
Gabapentin (GBP) is an organic cation mainly eliminated unchanged in urine, and active drug secretion has been suggested to contribute to its renal excretion. Our objective was to evaluate the potential drug-drug interaction between GBP and cetirizine (CTZ), an inhibitor of transporters for organic cations. An open-label, 2-period, crossover, nonrandomized clinical trial was conducted in patients with neuropathic pain to evaluate the effect of CTZ on GBP pharmacokinetics.
View Article and Find Full Text PDFA high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was successfully developed for the simultaneous detection of gabapentin (GBP) and cetirizine (CTZ) in cell lysates. Multiple reaction monitoring (MRM) transitions were found for GBP, CTZ and deuterated internal standards of both, allowing a selective and sensitive detection. Limits of detection (LODs) of 0.
View Article and Find Full Text PDFPharmacogenomics (PGx) has emerged as an encouraging tool in chronic pain therapy. Genetic variations associated with drug effectiveness or adverse reactions (amitriptyline/nortriptyline/codeine/oxycodone/tramadol-CYP2D6, amitriptyline-CYP2C19, carbamazepine-HLA-A, carbamazepine/oxcarbazepine-HLA-B) can be used to guide chronic pain management. Despite this evidence, many obstacles still need to be overcome for the effective clinical implementation of PGx.
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