Publications by authors named "Ana Carolina Cardoso dos Santos Durao"
Article Synopsis
- The embryonic stage is a critical period for congenital abnormalities, with the central nervous system being particularly vulnerable to genetic, environmental, and epigenetic factors.
- A study investigated the impact of environmental tobacco smoke (ETS) on neuroinflammation in offspring from pregnant mice, exposing them to cigarette smoke and assessing the effects on their immune response.
- Results showed that mouse pups exposed to ETS had increased proinflammatory cytokines and decreased cell viability, suggesting that ETS may worsen neuroinflammation-related conditions later in life.
Environmental Tobacco Smoke During the Early Postnatal Period of Mice Interferes With Brain F-FDG Uptake From Infancy to Early Adulthood - A Longitudinal Study.
Front Neurosci
January 2020
Exposure to environmental tobacco smoke (ETS) is associated with high morbidity and mortality, mainly in childhood. Our aim was to evaluate the effects of postnatal ETS exposure in the brain 2-deoxy-2-[F]-fluoro-D-glucose (F-FDG) uptake of mice by positron emission tomography (PET) neuroimaging in a longitudinal study. C57BL/6J mice were exposed to ETS that was generated from 3R4F cigarettes from postnatal day 3 (P3) to P14.
View Article and Find Full Text PDFNeuromyelitis Optica Spectrum Disorder (NMOSD) is characterized as an autoimmune, inflammatory and demyelinating disease of the Central Nervous System (CNS). Its pathogenesis is due to the presence of anti-aquaporin 4 immunoglobulin G1 antibodies (anti-AQP4IgG), with presence of lymphocytes T Helper 1 and 17 (TH1 and TH17), in addition to previous neuroinflammation. The Mast cell (MC) is a granular cell present in all vascularized tissues, close to vessels, nerves, and meninges.
View Article and Find Full Text PDFIntroduction: The regular practice of physical exercise has been associated with beneficial effects on various pulmonary conditions. We investigated the mechanisms involved in the protective effect of exercise in a model of lipopolysaccharide (LPS)-induced acute lung injury (ALI).
Methods: Mice were divided into four groups: Control (CTR), Exercise (Exe), LPS, and Exercise + LPS (Exe + LPS).
Formaldehyde (FA) is an indoor and outdoor pollutant widely used by many industries, and its exposure is associated with inflammation and oxidative stress in the airways. Our previous studies have demonstrated the role of reactive oxygen species (ROS) in lung inflammation induced by FA inhalation but did not identify source of the ROS. In the present study, we investigate the effects of FA on the activities and gene expression of glutathione peroxidase (GPX), glutathione reductase (GR), glutathione S-transferase (GST), superoxide dismutase (SOD) 1 and 2, catalase (CAT), nitric oxide synthase (iNOS and cNOS) and cyclooxygenase (COX) 1 and 2.
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