Publications by authors named "Ana Carolina B M Maximo"
Cell Host Microbe
April 2024
Article Synopsis
- Chikungunya virus (CHIKV) can lead to severe diseases, including chronic arthritis and, in rare cases, neurological issues and death, primarily transmitted by mosquitoes.
- A comprehensive study revealed that deaths from CHIKV are linked to multi-organ infections, serious brain damage, and higher levels of inflammation in the body compared to survivors.
- The research also found that CHIKV infection disrupts the blood-brain barrier, leading to increased permeability and changes in protein expression, enhancing our understanding of CHIK pathophysiology and fatal outcomes.
Article Synopsis
- Chikungunya virus (CHIKV), transmitted by Aedes mosquitoes, has significantly affected Brazil since its introduction in 2013, leading to high case numbers and severe health outcomes, particularly in Ceará state.
- An extensive study utilized genomic sequencing, vector data, and epidemiological records to analyze over 250,000 confirmed cases of chikungunya across Brazil from 2013 to 2022, identifying seven distinct epidemic waves.
- The analysis revealed that females were more likely to be infected than males in Ceará, with a cumulative case-fatality ratio of 1.3 deaths per 1000 cases, and highlighted the recurrence of chikungunya in specific states like Ceará, Tocantins, and Pernambuco
