Publications by authors named "Ana Carla da Silva"
Larvicidal and Oviposition Activity of Commercial Essential Oils of Ledeb., (Blanco) Benth., L. and Their Combinations Against .
Molecules
December 2024
is a vector responsible for the transmission of various arboviruses and is considered by the World Health Organization to be one of the main public health problems in the world. This study evaluated the larvicidal and oviposition activity of essential oils from , and and their formulations. Chromatographic analysis by GCMS identified a total of 28, 52 and 18 compounds for the oils of the species , and , respectively.
View Article and Find Full Text PDFChagas disease (CD) is caused by the hemoflagellate protozoan Trypanosoma cruzi. The control of the infection depends of the innate and acquired immune response of host. Moreover, CD plays a significant role in the immune response, and, in this context, microalgae can be an interesting alternative due to its immunomodulatory and trypanocidal effects.
View Article and Find Full Text PDFDynamics of the Trypanosoma cruzi infection in adipose tissue: Assessing gene expression of PNPLA2, FASN, and ACAT1 under Benzonidazole treatment and indirect mononuclear immune cells interaction.
Mol Biochem Parasitol
June 2024
Article Synopsis
- Trypanosoma cruzi is a highly adaptable parasite that can infect various tissues, including adipose tissue (AT), and its interaction with immune cells may influence gene expression related to lipid metabolism.
- Treatment with Benzonidazole (Bz) did not effectively reduce T. cruzi infection levels in adipocytes, regardless of the presence of immune cells, suggesting treatment limitations.
- Despite not decreasing the infection, Bz treatment was found to alter gene expression in AT, particularly increasing levels of PNPLA2 and influencing fatty acid synthesis pathways, indicating potential impacts on lipid metabolism during parasite infection.
Due to the limitations of Chagas disease therapy, microalgae can be promising in the search of new trypanocidal compounds, since these organisms produce bioactive compounds with large pharmaceutical applications, including antiparasitic effects. In this work, trypanocidal activity of aqueous extract of and, for the first time, aqueous extract of were evaluated against trypomastigote forms of . In addition, cytotoxic activity in Vero cells was evaluated.
View Article and Find Full Text PDFPurpose: To compare the performance of two novel multipurpose disinfecting solutions (MPDS) in preventing silicone hydrogel contact lens dehydration, provide higher scores of subjective comfort and stable optical quality during a month of lens wear in neophyte volunteers.
Method: This is a prospective, double-blind, contralateral and randomised study involving the contra lateral use of Complete RevitaLens and Biotrue MPDS. Twenty-five neophytes wore Air Optix Aqua for 1 month.