Magnetic Nanoplatforms for Modification of Macromolecules: Synthesis, Characterization, and Photoinactivating Power of Cationic Nanoiman-Porphyrin Conjugates.

A nanoplatform concept was developed to synthesize accessible photoactive magnetic nanoparticles (MNPs) of FeO coated with silica. This approach was based on the covalent binding of 5,10,15,20-tetrakis(pentafluorophenyl)porphyrin (TPPF) to aminopropyl-grafted MNPs by nucleophilic aromatic substitution reaction (SAr) to obtain conjugate MNP-P1. After modification, the remaining pentafluorophenyl groups of TPPF attached to MNPs were substituted by dimethylaminoethoxy groups to form MNP-P2.

Functionalized Magnetic Nanoparticles with BODIPYs for Bioimaging and Antimicrobial Therapy Applications.

The antimicrobial capability and recyclability of two conjugates that combines the versatility of iron oxide magnetic nanoparticles (MNPs) with the high photosensitizing proficiency of boron-dipyrromethene (BODIPY) dyes are assessed. By a relatively simple synthetic pathway, two conjugates were obtained. The first one, MNP-B1, contains a highly fluorescent dye for bioimaging and suitable inactivating properties.

Porphyrins containing basic aliphatic amino groups as potential broad-spectrum antimicrobial agents.

New porphyrin derivatives bearing basic aliphatic amino groups were synthesized from the condensation of meso-4-[(3-N,N-dimethylaminopropoxy)phenyl]dipyrromethane, pentafluorobenzaldehyde and 4-(3-N,N-dimethylaminopropoxy)benzaldehyde. The reaction was catalyzed by trifluoroacetic acid in acetonitrile. This approach was used to obtain porphyrins with different patterns of substitution, of which three of them were isolated: 5,15-di(4-pentafluorophenyl)-10,20-di[4-(3-N,N-dimethylaminopropoxy)phenyl]porphyrin (FAPP), 5-(4-pentafluorophenyl)-10,15,20-tris[4-(3-N,N-dimethylaminopropoxy)phenyl]porphyrin (FAPP) and 5,10,15,20-tetrakis[4-(3-N,N-dimethylaminopropoxy)phenyl]porphyrin (TAPP).