Publications by authors named "Ana C S S Nastri"
Article Synopsis
- * From 2016 to 2018, an outbreak in 22 European countries reported 4,475 cases, with a significant number among men who have sex with men (MSM), which later spread to cities like São Paulo in Brazil.
- * In a study of 51 hepatitis A cases in São Paulo, a high percentage were male and many identified as MSM; the majority of HAV strains were similar to those from the earlier European outbreaks, highlighting the need for increased vaccination efforts in high-risk groups.
Article Synopsis
- A multicenter clinical trial was launched in January 2018 to test the effectiveness of sofosbuvir on yellow fever (YF) during a significant outbreak in Brazil.
- Despite the urgent need due to rising cases, the approval process faced many regulatory and ethical challenges that slowed progress.
- By April 2018, only 29 out of a target of 90 patients were enrolled, indicating a need for better preparedness for rapid research in future outbreak situations.
Tegumentary leishmaniasis (TL) diagnosis is challenging due to the lack of a gold standard diagnostic tool. The diagnosis is significantly harder in regions where visceral leishmaniasis (VL) is also prevalent since immunological tests may present cross-reactivity. A cirrhotic patient from an endemic Brazilian region for TL and VL presented with atypical cutaneous lesions, a usual clinico-laboratory feature of VL (including a positive rk39 test result), but he was diagnosed with TL histopathologically; VL was ruled out by necropsy.
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- - Yellow fever (YF) remains a significant health threat despite effective vaccines, as seen in a 2018 outbreak in São Paulo, Brazil, in areas previously free from the virus.
- - This study examined 62 severe YF cases, identifying key clinical and laboratory factors linked to outcomes, such as liver enzyme levels and other biomarkers.
- - Findings indicate that lipase and factor V are strong predictors of mortality in YF patients, highlighting severe organ damage and the risks of liver failure in critical cases.
Hepatitis C virus (HCV) infection affects approximately 3 % of the world population. HCV targets hepatic tissue, and most infected patients develop a chronic infection. Currently, studies have demonstrated an association between HCV-RNA replication and miR-122, the most abundant microRNA in the liver.
View Article and Find Full Text PDFBackground: Nucleoside/nucleotide analogue (NA) treatment causes selection pressure for HBV strains carrying mutations conferring NA resistance. Drug-resistance mutations occur in the reverse transcriptase (RT) region of the HBV polymerase gene and spontaneously arise during viral replication. These mutations can also alter the hepatitis B surface (HBs) protein and in some cases reduce binding to HBs antibodies.
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