Foxo3 gene expression and oxidative status in beta-thalassemia minor subjects.

Background: Oxidative stress may aggravate symptoms of hemolytic anemias such as beta-thalassemia. FoxO3 activation results in resistance to oxidative stress in fibroblasts and neuronal cell cultures.

Objective: The purpose of this research was to study FoxO3 gene expression and oxidative status in beta-thalassemia minor individuals.

Molecular characterization and phenotypical study of β-thalassemia in Tucumán, Argentina.

The main hereditary hemoglobin (Hb) disorder in Argentina is β-thalassemia (β-thal). Molecular studies performed in the center of the country exhibited a marked prevalence of the codon 39 (C > T) and IVS-I-110 (G > A) mutations. The northwest region of Argentina has a different demographic history characterized by an important Spanish influx.