Publications by authors named "Ana Bruschy Fonseca"
Article Synopsis
- The study focuses on extensively drug-resistant Pseudomonas aeruginosa (XDR-PA) in a Portuguese hospital, highlighting its rising incidence, lack of effective treatment options, and high mortality rates.
- Over the course of three years, 178 cases of XDR-PA were documented, primarily affecting elderly male patients and often linked to respiratory and urinary infections, with notable risk factors including immunosuppression and major surgeries.
- Among the tested isolates, a small percentage were susceptible to certain antibiotics, with combination therapies being more effective, yet the overall death rate reached 35.1%, particularly higher in patients with certain types of cancer.
The carbapenem-resistant Enterobacterales (CRE) strains have been identified by the World Health Organization as critical priority pathogens in research and development of diagnostics, treatments, and vaccines. However, recent molecular information about carbapenem-resistant (CRK) epidemiology in Portugal is still scarce. Thus, this study aimed to provide the molecular epidemiology, resistome, and virulome of CRK clinical strains recovered from a tertiary care hospital centre (2019-2021) using polymerase chain reaction (PCR) and the advanced molecular technique whole-genome sequencing (WGS).
View Article and Find Full Text PDFThe combination of ceftazidime/avibactam (CZA) is a novel β-lactam/β-lactamase inhibitor with activity against carbapenemase (KPC)-producing Enterobacterales. Emerging cases caused by CZA-resistant strains that produce variants of KPC genes have already been reported worldwide. However, to the best of our knowledge, no CZA-resistant strains were reported in Portugal.
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