Upregulation of TLR4/MyD88 pathway in alcohol-induced Wernicke's encephalopathy: Findings in preclinical models and in a postmortem human case.

Wernicke's encephalopathy (WE) is a neurologic disease caused by vitamin B1 or thiamine deficiency (TD), being the alcohol use disorder its main risk factor. WE patients present limiting motor, cognitive, and emotional alterations related to a selective cerebral vulnerability. Neuroinflammation has been proposed to be one of the phenomena that contribute to brain damage.

MR-Proadrenomedullin as biomarker of renal damage in urinary tract infection in children.

Background: Midregional-proadrenomedullin (MR-proADM) is a useful prognostic peptide in severe infectious pathologies in the adult population. However, there are no studies that analyze its utility in febrile urinary tract infection (fUTI) in children. An accurate biomarker would provide an early detection of patients with kidney damage, avoiding other invasive tests like renal scintigraphy scans.

Gene polymorphisms associated with an increased risk of exudative age-related macular degeneration in a Spanish population.

Purpose: To identify the association between single-nucleotide polymorphisms (SNPs) in , and genes and exudative age-related macular degeneration (AMD) in a Spanish population.

Methods: In 187 exudative AMD patients and 196 healthy controls (61% women, mean age 75 years), 12 SNPs as risk factors for AMD in (rs1410996, rs1061170, r380390), ARMS2 (rs10490924, rs10490923), (rs11200638), (rs641153), (rs547154, rs9332739), and (rs147859257, rs2230199, rs1047286) genes were analyzed.

Results: The G allele was the most frequent in CFH gene (rs1410996) with a 7-fold increased risk of AMD (OR 7.