PPARα and PPARβ/δ are negatively correlated with proinflammatory markers in leukocytes of an obese pediatric population.

Background: Obesity configures a pathophysiological profile that predisposes the development of metabolic and cardiovascular diseases, critically impacting public health. The chronic dysregulation of immuno-metabolic components triggered by pediatric obesity is a common but scarcely understood aspect of the disease. Peroxisome proliferator-activated receptors (PPARs) are a group of transcription factors essential for energy and immune homeostasis of different tissues.

The skin aging index: a new approach for documenting anti-aging products or procedures.

Objective: The overall appearance of an aged skin is characterized by a combination of several attributes such as wrinkles, brown spots and sagging. Our objective was to develop and validate a statistical framework to assess the overall anti-ageing benefits of products/procedures.

Method: Different skin attributes were evaluated by a clinical grader and combined using a Principal Component Analysis (PCA).