Long-term results of linaclotide in the treatment of constipation-type irritable bowel syndrome.

Background: constipation-predominant irritable bowel syndrome (C-IBS) is a prevalent, complex and multifactorial disorder that represents a challenge in terms of diagnosis and therapeutic management.

Objective: to evaluate the effectiveness, safety and treatment satisfaction of linaclotide in C-IBS patients.

Methods: prospective, single-center and observational study conducted in patients diagnosed with C-IBS.

Overlap of reflux and eosinophilic esophagitis in two patients requiring different therapies: a review of the literature.

Eosinophilic esophagitis (EE) and gastroesophageal reflux disease (GERD) have overlapping clinical, manometric, endoscopic and histopathologic features. The diagnosis of EE is nowadays based upon the presence of 15 or more eosinophils per high power field (eo/HPF) in esophageal biopsies. We report the cases of two young males suffering from dysphagia and recurrent food impaction with reflux esophagitis and more than 20 eo/HPF in upper-mid esophagus biopsies, both of which became asymptomatic on proton pump inhibitor (PPI) therapy.