Publications by authors named "Ana Beatriz P L Stracieri"
Long-Term Effects of Allogeneic Hematopoietic Stem Cell Transplantation on Systemic Inflammation in Sickle Cell Disease Patients.
Front Immunol
February 2022
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only currently available curative treatment for sickle cell disease (SCD). However, the effects of HSCT on SCD pathophysiology are poorly elucidated. Here, we assessed red blood cell (RBC) adhesiveness, intensity of hemolysis, vascular tone markers and systemic inflammation, in SCD patients treated with allogeneic HSCT.
View Article and Find Full Text PDFHematopoietic stem cell transplantation reverses white matter injury measured by diffusion-tensor imaging (DTI) in sickle cell disease patients.
Bone Marrow Transplant
November 2021
Article Synopsis
- * The study used Diffusion Tensor Imaging (DTI) to assess white matter lesions in 28 SCD patients before and after receiving stem cell transplants, comparing them with 26 healthy individuals.
- * Results showed that while SCD patients had lower brain connectivity scores before transplantation, these scores improved post-treatment, suggesting that stem cell transplantation may help recover brain function in SCD patients.
The present review discusses the use of autologous hematopoietic stem cell transplantation (HSCT) for the treatment of diabetes mellitus type 1 (DM 1). It has been observed that high dose immunosuppression followed by HSCT shows better results among other immunotherapeutic treatments for the disease as the patients with adequate beta cell reserve achieve insulin independence. However, this response is not maintained and reoccurrence of the disease is major a major challenge to use HSCT in future to prevent or control relapse of DM 1.
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