Publications by authors named "Ana Beatriz Ferreira Barletta"
Prostaglandins (PGs) are immuno-active lipids that mediate the immune response in invertebrates and vertebrates. In insects, PGs play a role on different physiological processes such as reproduction, ion transport and regulation of cellular immunity. However, it is unclear whether PGs play a role in invertebrate's humoral immunity, and, if so, which immune signaling pathways would be modulated by PGs.
View Article and Find Full Text PDFBackground: Aedes aegypti is the main vector of important arboviruses such as dengue, Zika and chikungunya. During infections mosquitoes can activate the immune pathways Toll, IMD and JAK/STAT to limit pathogen replication.
Results: Here, we evaluate the immune response profile of Ae.
Article Synopsis
- Lipid droplets (LDs) are tiny structures in cells that help control how the immune system works in mammals.
- Scientists found that mosquito cells build up LDs when they are attacked by certain viruses and bacteria, like Dengue virus.
- The study shows that LDs might play an important part in how mosquitoes fight off infections, which could lead to more research on how insects react to germs.
Background: The understanding of mosquito immune responses can provide valuable tools for development of novel mosquito control strategies. Aiming the study at insect innate immunity, continuous insect cell lines have been established and used as research tools due to the fact that they constitute more homogeneous, sensitive, and reproducible systems than the insects from which they originated. More recently, Aag-2, an Aedes aegypti cell lineage, began to be frequently used as a model for studies of mosquito immunity.
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