Publications by authors named "Ana Beatriz Barra"
High-volume hemodiafiltration decreases the pre-dialysis concentrations of indoxyl sulfate and p-cresyl sulfate compared to hemodialysis: a post-hoc analysis from the HDFit randomized controlled trial.
J Nephrol
June 2022
Background: Although high-volume online hemodiafiltration has been associated with higher clearance and lower pre-dialysis concentration of middle molecular weight toxins compared to hemodialysis, its effect on protein-bound uremic toxins has shown inconclusive results. In this study, we investigated whether hemodiafiltration impacts pre-dialysis plasma levels of the toxins indoxyl sulfate, p-cresyl sulfate, and indole-3-acetic acid compared to high-flux hemodialysis.
Methods: This is a post-hoc analysis of the multicenter, randomized controlled trial HDFit (ClinicalTrials.
Design and methodology of the impact of HemoDiaFIlTration on physical activity and self-reported outcomes: a randomized controlled trial (HDFIT trial) in Brazil.
BMC Nephrol
March 2019
Background: End stage renal disease (ESRD) patients require a renal replacement therapy (RRT) to filter accumulated toxins and remove excess water, which are associated with impaired physical function. Hemodialysis (HD) removes middle-molecular weight (MMW) toxins less efficiently compared to hemodiafiltration (HDF); we hypothesized HDF may improve physical function. We detailed the design and methodology of the HDFIT protocol that is testing whether changing from HD to HDF effects physical activity levels and various outcomes.
View Article and Find Full Text PDFBackground: Chronic kidney disease (CKD) patients develop metabolic acidosis when approaching stages 3 and 4, a period in which accelerated atherogenesis may ensue. Studies in vitro show that low pH may increase low-density lipoprotein (LDL) oxidation, suggesting a role for chronic metabolic acidosis in atherosclerosis. The present study attempted to evaluate the effects of conservative care using oral sodium bicarbonate (NaHCO) supplementation on the electronegative LDL [LDL(-)], a minimally oxidized LDL, plasma levels in CKD patients.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to determine how early changes in serum albumin (sAlb) levels affect the two-year mortality of new hemodialysis patients.
- A total of 1,679 patients were analyzed, showing a higher mortality rate in those with low initial sAlb levels, particularly if their levels increased over the first three months.
- The findings suggest that early sAlb changes are crucial for predicting mortality; rising sAlb levels in patients with low initial values indicate a better prognosis, while decreasing sAlb levels in patients with adequate initial values worsen their survival outlook.