Publications by authors named "Ana Bace"
Background: The epidemic pattern of respiratory syncytial virus (RSV) is quite different in regions of Europe (biennial epidemics in alternating cycles of approximately 9 and 15 months) than in the Western Hemisphere (annual epidemics). In order to determine if these differences are accounted for by the circulation of different RSV subtypes, we studied the prevalence of RSV subtype A and B strains in Zagreb County from 1 January 2006 to 31 December 2007.
Results: RSV was identified in the nasopharyngeal secretions of 368 inpatients using direct fluorescence assays and/or by virus isolation in cell culture.
Human metapneumovirus (HMPV) is an important respiratory pathogen, especially among young children. The genetic characteristics of HMPV circulating in Croatia have not been studied so far. The aim of this study was to determine the incidence of HMPV infection in hospitalized children with acute respiratory tract infection (ARTI) in the season 2005/2006 in Croatia, as well as to perform the genotypic analysis of detected HMPV strains.
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- RSV glycoprotein G mimics fractalkine, affecting chemotaxis in leukocytes with the CX(3)CR1 receptor, prompting the study of its impact on CD8(+) T cells in infants with RSV bronchiolitis.
- Samples were taken from affected infants during acute and recovery phases, and their perforin and IFN-gamma levels were analyzed compared to healthy controls.
- Findings revealed lower perforin and CX(3)CR1 levels in the recovery phase of infected infants, suggesting that RSV infection might have lasting effects on T cell functions and link disease severity to CX(3)CR1 expression.