Water soluble organometallic small molecules as promising antibacterial agents: synthesis, physical-chemical properties and biological evaluation to tackle bacterial infections.

The Na[3,3'-Fe(8-I-1,2-CBH)] and Na[2,2'-M(1,7-CBH)] (M = Co, Fe) small molecules are synthesized and the X-ray structures of [(HO)(HO)][2,2'-Co(1,7-CBH)] and [Cs(MeCN)][8,8'-I-Fe(1,2 CBH)], both displaying a conformation of the [M(CB)] framework, are reported. Importantly, the supramolecular structure of [(HO)(HO)][2,2'-Co(1,7-CBH)] presents 2D layers leading to a lamellar arrangement of the anions while the cation layers form polymeric water rings made of six- and four-membered rings of water molecules connected OH⋯H hydrogen bonds; B-H⋯O contacts connect the cationic and anionic layers. Herein, we highlight the influence of the ligand isomers (-/-), the metal effect (Co/Fe) on the same isomer, as well as the influence of the presence of the iodine atoms on the physical-chemical and biological properties of these molecules as antimicrobial agents to tackle antibiotic-resistant bacteria, which were tested with four Gram-positive bacteria, five Gram-negative bacteria, and three strains that have been responsible for human infections.

1.3 V Inorganic Sequential Redox Chain with an All-Anionic Couple 1-/2- in a Single Framework.

The relatively low symmetry of [3,3'-Co(1,2-CBH)] ([]), along with the high number of available substitution sites, 18 on the boron atoms and 4 on the carbon atoms, allows a fairly regioselective and stepwise chlorination of the platform and therefore a very controlled tuning of the electrochemical potential tuning. This is not so easily found in other systems, e.g.

A fast and simple B-C bond formation in metallacarboranes avoiding halometallacarboranes and transition metal catalysts.

An electrophilic substitution on metallacarboranes by using a stabilized carbocation that can be made in situ is reported for the first time. This new synthetic methodology provides a new perspective on easy metallacarborane derivatization with organic fragments, which enhances the properties of both fragments and widens their possible applications.

Slow-spin relaxation of a low-spin S = 1/2 Fe carborane complex.

In this communication, we report the first evidence of slow-spin relaxation of a low-spin FeIII carborane complex. Iron S = 1/2 complexes showing such behaviour are particularly appealing as qubit candidates because they fulfil some of the main requirements to reach long decoherence times, such as moderate magnetic anisotropy, small spin, metal element mainly with zero-nuclear spin and furthermore, large versatility to introduce chemical modifications.

Electron Accumulative Molecules.

With the goal to produce molecules with high electron accepting capacity and low reorganization energy upon gaining one or more electrons, a synthesis procedure leading to the formation of a B-N(aromatic) bond in a cluster has been developed. The research was focused on the development of a molecular structure able to accept and release a specific number of electrons without decomposing or change in its structural arrangement. The synthetic procedure consists of a parallel decomposition reaction to generate a reactive electrophile and a synthesis reaction to generate the B-N(aromatic) bond.