Publications by authors named "Ana Alves"

In horses, basal cell neoplasms are uncommon benign tumors with slow growth mostly reported in the skin and eyelid. Malignant presentation is even more uncommon. This report describes a basal cell carcinoma (BCC) in the periocular region of a 10-year-old donkey.

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Renal cell carcinoma is rarely reported in pregnant women. Diagnosis is often delayed because symptoms are similar to physiological changes and disorders of pregnancy. Each case should be discussed on an individual basis because there are no guidelines described for the clinical management of this disease during pregnancy.

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Objective: Evaluate the influence of photobiomodulation in a model of oral carcinogenesis induced by 4-nitroquinoline-n-oxide (4-NQO).

Subjective: Ninety-six Swiss mice received topical application of 1% 4-NQO on tongue dorsum, for 20 weeks. The tongue was subjected to photobiomodulation with red (71.

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Fluorescence recovery after photobleaching (FRAP) can be employed to investigate membrane lipid mixing of vacuoles in live budding yeast cells and distinguish the fused, hemi-fused or non-fused states of these organelles under physiological conditions. Here, we describe a protocol for labeling the outer and inner leaflets of vacuoles in live cells that allow to detect hemifusion intermediates and, thus, identify components necessary for fusion pore opening.

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Background: Breast cancer treatments often cause serious side effects, but physical exercise has shown the potential to improve both the physical and psychological health outcomes of survivors. This review and meta-analysis aimed to synthesize and analyze the scientific evidence on the effectiveness of concurrent training on physical, psychological, and biomarkers variables on breast cancer survivors.; Methods: A systematic review and meta-analysis was registered in PROSPERO (CRD42024571851).

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Placenta accreta represents a spectrum of adherent placental anomalies and is an atypical invasion of the placenta. The major predisposing factor is a prior cesarean delivery. Placenta previa is considered an additional risk factor.

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Human Pose Estimation (HPE) is a computer vision application that utilizes deep learning techniques to precisely locate Key Joint Points (KJPs), enabling the accurate description of a person's pose. HPE models can be extended to facilitate Range of Motion (ROM) assessment by leveraging patient photographs. This study aims to evaluate and compare the performance of HPE models for assessing upper limbs ROM.

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Introduction: Neoadjuvant cisplatin-based chemotherapy followed by radical surgery is the standard treatment for muscle-invasive urothelial carcinoma (MIUC). The Checkmate-274 and AMBASSADOR trials have demonstrated improvements in disease-free survival (DFS) with adjuvant immunotherapy. Consequently, this meta-analysis aimed to assess the effectiveness of strategies involving checkpoint inhibitors in managing high-risk MIUC.

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This study aimed to assess the immediate effects of transcutaneous spinal direct current stimulation (tsDCS) on pain outcomes, measured using the visual analog scale (VAS) and pressure pain thresholds in a cohort of 55 participants experiencing chronic pain using a controlled, randomized trial with 55 participants allocated into 2 groups: 2 mA and 0.5 mA of tsDCS for 20 min. Anodal stimulation was applied on the 12th thoracic vertebra, with the cathode positioned on the 7th cervical vertebra.

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This study explores the bioactive potential of banana leaf extracts and their innovative integration into knitted hemp fabrics. To obtain the extracts, distinct extraction methodologies were employed, namely conventional extraction, ultrasound-assisted extraction, and pressurized-liquid extraction. Aqueous and hydroethanolic solvents, namely 20% (/) and 50% (/), were employed during the extraction process.

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This case report discusses a unique case of renal eventration in a cat resulting from a lumbar hernia possibly of traumatic origin. A two-year-old indoor/outdoor male neutered domestic shorthair was evaluated for a rapidly growing mass noted in the right lumbar region. Initial physical examination revealed a firm, circular and slightly mobile mass in the lumbar region, along with pain and tenderness on palpation.

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Background: Reverse the fat accumulation and to improve body contouring with more safely than invasive procedures has become a necessary therapeutic approach, but little detailed when using LED photobiomodulation.

Aims: To evaluate an application protocol with two different wavelengths (red and infrared LED) consecutively in the abdomen region alone or associated with the dermocosmetics application with lipolytic properties.

Methods: Ninety patients with a significant amount of adipose tissue in the abdomen region were selected and randomized into three groups: Sham (SG), in which patients received a simulation of the treatment; LED (LG), in which participants received the application with LED; LED with dermocosmetic (LDG), in which the participants underwent a combination of LED and dermocosmetic treatment.

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Article Synopsis
  • The study aimed to assess how MMR complex protein expression affects disease-free survival in oropharyngeal squamous cell carcinoma (SCC) patients who were treated non-surgically.
  • Data from 85 cases were analyzed, focusing on clinical-pathological information and immunohistochemical markers (MSH2, MSH6, PMS2, MLH1, and p16) to identify correlations with patient outcomes.
  • Results showed that loss of MSH2 in p16- tumors led to shorter disease-free survival, while in p16+ tumors, loss of MSH2 was linked to longer survival, indicating that imbalances in MMR proteins play a crucial role in treatment resistance and patient prognosis.
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: Incidence of cardiovascular disease (CVD) is increasing in low- and middle-income countries because of changing lifestyles. Since dyslipidaemia is a major independent cardiovascular risk factor, its correct identification is critical to implement specific interventions for CVD prevention. This study aimed to characterise the lipid profile of the Portuguese population.

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Fungal rhinitis in horses is rare, although severe, due to the progressive nasal obstruction. Aspergillus is one of the fungi most often involved in these cases. A 7-year-old Quarter Horse mare weighing 325 kg was admitted with a history of recurrent nasal discharge and bleeding, foul smell, reluctance to exercise, and abortion.

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Vascular hamartoma is an abnormal development of endothelial tissue that rarely affects horses. Histopathological examination remains the gold standard for definitive diagnosis, yet the presence of abnormal vascular structures must be carefully differentiated from other vascular anomalies and neoplasms. This report describes two cases of vascular proliferation affecting the skin on the lateral side over the left tarsus and the dorsolateral region over the fetlock joint of two fillies.

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Two monoterpenoid lactones, loliolide () and -loliolide (), were isolated from the crude dichloromethane extract of a microalga, sp.). The structures of loliolide () and -loliolide () were elucidated by 1D and 2D NMR analysis, as well as a comparison of their H or/and C NMR data with those reported in the literature.

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Article Synopsis
  • Hepatic fibrosis involves excessive collagen buildup in the liver, affecting its normal function and structure.
  • The study shows that using human amniotic membrane (AM) as a patch on the liver significantly reduces collagen levels in a rat model of biliary fibrosis.
  • Results indicated that AM treatment increased the expression of matrix metalloproteinase 12 (MMP12), which helps lower collagen accumulation, suggesting a potential therapeutic role for AM in treating liver fibrosis.
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Article Synopsis
  • - The text discusses common technologies in tissue engineering, focusing on growth factor therapies, metal implants (like titanium), 3D bioprinting, nanoimprinting for scaffolds, and cell therapies, particularly mesenchymal stem cells (MSCs), as promising alternatives to organ transplants for musculoskeletal diseases.
  • - MSCs are highlighted for their unique abilities to self-renew, regenerate tissues, and modulate immune responses, making them increasingly popular in regenerative medicine.
  • - The review emphasizes ongoing research in developing biomaterials that enhance the differentiation and expansion of MSCs, detailing their impacts through various studies, including experimental and clinical research using sheep models.
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This study aimed to evaluate the influence in torrefaction of the chemical structure of biomasses from nine poplar commercial SRC clones, evaluated through analytical pyrolysis. The chemical data were integrated into a dataset including LHV gain, representative of torrefaction aptitude and six chemical variables obtained through analytical pyrolysis, which were: (i) CHCl extractives; (ii) total extractives; (iii) Py-lignin; (iv) holocellulose; (v) (syringil/guaiacyl) ratio; and (vi) (pentosan/hexosan) ratio. Significant univariate and bivariate linear relations were obtained with LHV gain from torrefaction as dependent variable vs.

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To date, no studies comparing the prevalence of hepatitis E virus (HEV) infection between the general and human immunodeficiency virus 2 (HIV-2) populations are available. With the purpose of filling this gap, this prevalence was assessed in the HIV-2 population from central Portugal. HEV seropositivity was 19.

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The progression of obesity involves several molecular mechanisms that are closely associated with the pathophysiological response of the disease. Endoplasmic reticulum (ER) stress is one such factor. Lipotoxicity disrupts endoplasmic reticulum homeostasis in the context of obesity.

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Article Synopsis
  • Behçet's disease (BD) is a multisystem inflammatory condition that can impact the nervous system, sometimes referred to as neuro-Behçet.
  • A 46-year-old woman with a history of BD was admitted for severe neck pain and neurological symptoms, leading to a brain MRI that indicated a possible diagnosis of neuro-Behçet.
  • The patient was treated with corticosteroids and azathioprine, resulting in significant clinical improvement and resolution of the brain lesion, underscoring the need for precise diagnosis and timely treatment.
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Article Synopsis
  • Leprosy is primarily driven by the host's biological and immunological characteristics, impacting disease pathology more than the bacterium itself.
  • A systematic review was conducted on 49 articles to explore the connection between immunopathology and leprosy severity, focusing on MHC molecule release, and various immune cell roles.
  • The study concludes that while the adaptive immune system worsens nerve damage and influences leprosy type, the innate immune system plays a crucial role in the disease's onset and initial immune responses.
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